Mouse Anti-KISS1 Recombinant Antibody (A766) (CBMAB-AP4162LY)

Name: Mouse Anti-KISS1 Recombinant Antibody (A766)
SKU: CBMAB-AP4162LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A766

Application

ICC, IHC, IP, WB

Immunogen

RPC559Hu01-Recombinant Kisspeptin 1 (KISS1)

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

KiSS-1 Metastasis Suppressor

Introduction

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]

Entrez Gene ID

3814

UniProt ID

Q15726

Alternative Names

KiSS-1 Metastasis Suppressor; Prepro-Kisspeptin; Kisspeptin-1; Malignant Melanoma Metastasis-Suppressor; Metastasis-Suppressor KiSS-1; KiSS-1 Metastasis-Suppressor;

Function

MAC559Hu22

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Generation of ovulation cycle rhythmIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathwayIEA:Ensembl
Positive regulation of growth hormone secretionIEA:Ensembl
Positive regulation of luteinizing hormone secretionIEA:Ensembl
Positive regulation of MAPK cascadeIEA:Ensembl
Positive regulation of synaptic transmissionIEA:Ensembl

Cellular Location

Secreted

Involvement in disease

Hypogonadotropic hypogonadism 13 with or without anosmia (HH13):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

PTM

Processed by MMP2 and MMP9.

Li, Z., Liu, J., Inuzuka, H., & Wei, W. (2022). Functional analysis of the emerging roles for the KISS1/KISS1R signaling pathway in cancer metastasis. Journal of Genetics and Genomics, 49(3), 181-184.

Ly, T., Harihar, S., & Welch, D. R. (2020). KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer and Metastasis Reviews, 39(3), 739-754.

Talbi, R., & Navarro, V. M. (2020). Novel insights into the metabolic action of Kiss1 neurons. Endocrine connections, 9(5), R124-R133.

Ikegami, K., Goto, T., Nakamura, S., Watanabe, Y., Sugimoto, A., Majarune, S., ... & Uenoyama, Y. (2020). Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice. Journal of Reproduction and Development, 66(4), 359-367.

Ulasov, I. V., Borovjagin, A. V., Timashev, P., Cristofanili, M., & Welch, D. R. (2019). KISS1 in breast cancer progression and autophagy. Cancer and Metastasis Reviews, 38, 493-506.

Yeo, S. H., Kyle, V., Blouet, C., Jones, S., & Colledge, W. H. (2019). Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PloS one, 14(3), e0213927.

Guzman, S., Brackstone, M., Radovick, S., Babwah, A. V., & Bhattacharya, M. M. (2018). KISS1/KISS1R in cancer: friend or foe?. Frontiers in endocrinology, 9, 437.

Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., ... & Tena-Sempere, M. (2018). SIRT1 mediates obesity-and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nature communications, 9(1), 4194.

Kostakis, I. D., Agrogiannis, G., Vaiopoulos, A. G., Mylona, E., Patsouris, E., Kouraklis, G., & Koutsilieris, M. (2018). KISS1 and KISS1R expression in gastric cancer. J buon, 23(01), 79-84.

Chakravarthi, V. P., Khristi, V., Ghosh, S., Yerrathota, S., Dai, E., Roby, K. F., ... & Rumi, M. K. (2018). ESR2 is essential for gonadotropin-induced Kiss1 expression in granulosa cells. Endocrinology, 159(11), 3860-3873.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

KISS1 Matched Antibody Pair (667) (CAT#: APMAB-667LY)

Related Products

Mouse Anti-KISS1 Recombinant Antibody (1F7) (CAT#: CBMAB-K0955-LY)

KISS1 Matched Antibody Pair (667) (CAT#: APMAB-667LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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