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KISS1 Matched Antibody Pair (667) (APMAB-667LY)

This antibody pair set can be used for detecting and quantifying protein level of human KISS1.
See all KISS1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-KISS1 monoclonal, IgG2a antibody, 100 ug
Detection Antibody
Anti-KISS1 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
Alternative Names
KiSS-1 Metastasis Suppressor; Prepro-Kisspeptin; Kisspeptin-1; Malignant Melanoma Metastasis-Suppressor; Metastasis-Suppressor KiSS-1; KiSS-1 Metastasis-Suppressor;
Entrez Gene ID
3814
UniProt ID
Q15726

Li, Z., Liu, J., Inuzuka, H., & Wei, W. (2022). Functional analysis of the emerging roles for the KISS1/KISS1R signaling pathway in cancer metastasis. Journal of Genetics and Genomics, 49(3), 181-184.

Ly, T., Harihar, S., & Welch, D. R. (2020). KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer and Metastasis Reviews, 39(3), 739-754.

Talbi, R., & Navarro, V. M. (2020). Novel insights into the metabolic action of Kiss1 neurons. Endocrine connections, 9(5), R124-R133.

Ikegami, K., Goto, T., Nakamura, S., Watanabe, Y., Sugimoto, A., Majarune, S., ... & Uenoyama, Y. (2020). Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice. Journal of Reproduction and Development, 66(4), 359-367.

Ulasov, I. V., Borovjagin, A. V., Timashev, P., Cristofanili, M., & Welch, D. R. (2019). KISS1 in breast cancer progression and autophagy. Cancer and Metastasis Reviews, 38, 493-506.

Yeo, S. H., Kyle, V., Blouet, C., Jones, S., & Colledge, W. H. (2019). Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PloS one, 14(3), e0213927.

Guzman, S., Brackstone, M., Radovick, S., Babwah, A. V., & Bhattacharya, M. M. (2018). KISS1/KISS1R in cancer: friend or foe?. Frontiers in endocrinology, 9, 437.

Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., ... & Tena-Sempere, M. (2018). SIRT1 mediates obesity-and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression. Nature communications, 9(1), 4194.

Kostakis, I. D., Agrogiannis, G., Vaiopoulos, A. G., Mylona, E., Patsouris, E., Kouraklis, G., & Koutsilieris, M. (2018). KISS1 and KISS1R expression in gastric cancer. J buon, 23(01), 79-84.

Chakravarthi, V. P., Khristi, V., Ghosh, S., Yerrathota, S., Dai, E., Roby, K. F., ... & Rumi, M. K. (2018). ESR2 is essential for gonadotropin-induced Kiss1 expression in granulosa cells. Endocrinology, 159(11), 3860-3873.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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