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Mouse Anti-KLF15 Recombinant Antibody (2G8) (CBMAB-K1072-LY)

This product is antibody recognizes KLF15. The antibody 2G8 immunoassay techniques such as: ELISA, WB, IHC-P, IF/ICC, FC.
See all KLF15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G8
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, IF/ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human KLF15 expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.03% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel Like Factor 15
Introduction
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Entrez Gene ID
28999
UniProt ID
Q9UIH9
Alternative Names
Kruppel Like Factor 15; Kidney-Enriched Krueppel-Like Factor; Kidney-Enriched Kruppel-Like Factor; KKLF; Krueppel-Like Factor 15;
Function
Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.
Biological Process
Protein localization to lysosomeISS:UniProtKB
Protein stabilizationISS:UniProtKB
Cellular Location
Lysosome membrane
PTM
Not N-glycosylated.

Fan, L., Sweet, D. R., Fan, E. K., Prosdocimo, D. A., Madera, A., Jiang, Z., ... & Jain, M. K. (2022). Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. Journal of Biological Chemistry, 298(6).

Suzuki, N., Kanai, A., Suzuki, Y., Ogino, H., & Ochi, H. (2022). Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction. Proceedings of the National Academy of Sciences, 119(33), e2204338119.

Anzai, K., Tsuruya, K., Ida, K., Kagawa, T., Inagaki, Y., & Kamiya, A. (2021). Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts. Scientific Reports, 11(1), 18551.

Zhao, Y., Song, W., Wang, L., Rane, M. J., Han, F., & Cai, L. (2019). Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications. Journal of Molecular and Cellular Cardiology, 129, 193-196.

Li, Y., Zhao, M., & Xiao, W. (2018). KLF15 regulates the expression of MMP-3 in human chondrocytes. Journal of Interferon & Cytokine Research, 38(8), 356-362.

Guo, H., Khan, R., Raza, S. H. A., Ning, Y., Wei, D., Wu, S., ... & Zan, L. (2018). KLF15 promotes transcription of KLF3 gene in bovine adipocytes. Gene, 659, 77-83.

Wang, X., He, M., Li, J., Wang, H., & Huang, J. (2018). KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma. Biomedicine & Pharmacotherapy, 106, 672-677.

Gu, X., Xu, D., Fu, L., Wang, Y., Mei, C., & Gao, X. (2018). KLF 15 works as an early anti-fibrotic transcriptional regulator in Ang II-induced renal fibrosis via down-regulation of CTGF expression. Kidney and Blood Pressure Research, 42(6), 999-1012.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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