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Mouse Anti-KLHL13 Recombinant Antibody (13B456) (CBMAB-K1180-LY)

This product is antibody recognizes KLHL13. The antibody 13B456 immunoassay techniques such as: ELISA, FC, IHC, WB.
See all KLHL13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13B456
Antibody Isotype
IgG1
Application
ELISA, FC, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human KLHL13 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.03% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kelch Like Family Member 13
Introduction
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Entrez Gene ID
90293
UniProt ID
Q9P2N7
Alternative Names
Kelch Like Family Member 13; BKLHD2; BTB And Kelch Domain Containing 2; KIAA1309; BTB And Kelch Domain-Containing Protein 2; BTB And Kelch Domain Containing 2; Kelch-Like 13 (Drosophila); Kelch-Like Protein 13; Kelch-Like 13; KIAA1309;
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
Biological Process
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cul3-RING ubiquitin ligase complex: Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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