KLHL13

This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Full Name
Kelch Like Family Member 13
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
Biological Process
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cul3-RING ubiquitin ligase complex: Cytosol
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Anti-KLHL13 antibodies

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Mouse Anti-KLHL13 Recombinant Antibody (8D1) (CBMAB-K1181-LY)

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Target: KLHL13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D1
Application*: E, WB, P, IF/IC, F
Datasheet SDS

Mouse Anti-KLHL13 Recombinant Antibody (13B456) (CBMAB-K1180-LY)

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Target: KLHL13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B456
Application*: E, F, IH, WB
Datasheet SDS

Mouse Anti-KLHL13 Recombinant Antibody (CBT815) (V2LY-0625-LY3248)

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Target: KLHL13
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT815
Application*: WB, P, IF, IC, F, E
Datasheet SDS

Mouse Anti-KLHL13 Recombinant Antibody (CBT4530) (V2LY-0625-LY2466)

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Target: KLHL13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4530
Application*: WB, IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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