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Mouse Anti-KLKB1 Recombinant Antibody (1D10) (CBMAB-P0446-YC)

Provided herein is a Mouse monoclonal antibody against Human Kallikrein B1. The antibody can be used for immunoassay techniques, such as WB, ELISA, ICC, IF.
See all KLKB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D10
Antibody Isotype
IgG1, κ
Application
WB, ELISA, ICC, IF

Basic Information

Immunogen
Recombinant human KLK3(25-261aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Kallikrein B1
Introduction
KLKB1 is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency.
Entrez Gene ID
3818
UniProt ID
P03952
Alternative Names
Kallikrein B1; Kallikrein B, Plasma (Fletcher Factor) 1; Plasma Prekallikrein; Fletcher Factor; Kininogenin; KLK3; PKK;
Function
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Biological Process
Blood coagulationIEA:UniProtKB-KW
Blood coagulation, intrinsic pathwayIDA:ComplexPortal
Factor XII activationManual Assertion Based On ExperimentTAS:BHF-UCL
FibrinolysisIEA:UniProtKB-KW
Plasminogen activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fibrinolysisManual Assertion Based On ExperimentIDA:BHF-UCL
ProteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Zymogen activationManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Secreted
Involvement in disease
Prekallikrein deficiency (PKK deficiency):
This disorder is a blood coagulation defect.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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