KLKB1
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Full Name
Kallikrein B1
Function
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Biological Process
Blood coagulationIEA:UniProtKB-KW
Blood coagulation, intrinsic pathwayIDA:ComplexPortal
Factor XII activationManual Assertion Based On ExperimentTAS:BHF-UCL
FibrinolysisIEA:UniProtKB-KW
Plasminogen activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fibrinolysisManual Assertion Based On ExperimentIDA:BHF-UCL
ProteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Zymogen activationManual Assertion Based On ExperimentIDA:ComplexPortal
Blood coagulation, intrinsic pathwayIDA:ComplexPortal
Factor XII activationManual Assertion Based On ExperimentTAS:BHF-UCL
FibrinolysisIEA:UniProtKB-KW
Plasminogen activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fibrinolysisManual Assertion Based On ExperimentIDA:BHF-UCL
ProteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Zymogen activationManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Secreted
Involvement in disease
Prekallikrein deficiency (PKK deficiency):
This disorder is a blood coagulation defect.
This disorder is a blood coagulation defect.
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Anti-KLKB1 antibodies
+ Filters
Target: KLKB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D10
Application*: WB, E, IC, IF
Target: KLKB1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 7H97
Application*: E, WB
Target: KLKB1
Sensitivity: 2.11 mU/mL
Detection Range: 5-1000 mU/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Klkb1
Sensitivity: 0.58 ng/mL
Detection Range: 1-400 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Klkb1
Sensitivity: 1.52 ng/mL
Detection Range: 3-900 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: KLKB1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-638
Tag: His Tag
Target: KLKB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9F6
Application*: E, IH
Target: KLKB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1804
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Target: KLKB1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYC-P095
Application*: WB
Target: KLKB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 901
Application*: E, FN, WB
Target: KLKB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13G11
Application*: E, WB
Target: KLKB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-126
Application*: WB, IP, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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