KLKB1

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Full Name
Kallikrein B1
Function
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Biological Process
Blood coagulationIEA:UniProtKB-KW
Blood coagulation, intrinsic pathwayIDA:ComplexPortal
Factor XII activationManual Assertion Based On ExperimentTAS:BHF-UCL
FibrinolysisIEA:UniProtKB-KW
Plasminogen activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fibrinolysisManual Assertion Based On ExperimentIDA:BHF-UCL
ProteolysisManual Assertion Based On ExperimentIDA:ComplexPortal
Zymogen activationManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Secreted
Involvement in disease
Prekallikrein deficiency (PKK deficiency):
This disorder is a blood coagulation defect.
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Anti-KLKB1 antibodies

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Mouse Anti-KLKB1 Recombinant Antibody (1D10) (CBMAB-P0446-YC)

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Target: KLKB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D10
Application*: WB, E, IC, IF
Datasheet SDS

Rat Anti-KLKB1 Recombinant Antibody (7H97) (CBMAB-K1391-LY)

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Target: KLKB1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 7H97
Application*: E, WB
Datasheet SDS

Rabbit Anti-KLKB1 Recombinant Antibody (EG1804) (CBMAB-EN2163-LY)

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Target: KLKB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1804
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Datasheet SDS

Rat Anti-KLKB1 Recombinant Antibody (CBYC-P095) (CBMAB-P0447-YC)

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Target: KLKB1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYC-P095
Application*: WB
Datasheet SDS

Mouse Anti-KLKB1 Recombinant Antibody (901) (CBMAB-K1392-LY)

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Target: KLKB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 901
Application*: E, FN, WB
Datasheet SDS

Mouse Anti-KLKB1 Recombinant Antibody (13G11) (CBMAB-K1390-LY)

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Target: KLKB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13G11
Application*: E, WB
Datasheet SDS

Rabbit Anti-KLKB1 Recombinant Antibody (CBLY1-126) (CBMAB-K1389-LY)

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Target: KLKB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-126
Application*: WB, IP, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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