Human Anti-KLRC2 Recombinant Antibody (CBXC-0743) (CBMAB-C1857-CQ)

This product is a recombinant human antibody that recognizes KLRC2. The antibody CBXC-0743 can be used for immunoassay techniques such as: FC.
See all KLRC2 antibodies

Datasheet

Summary

Host Animal

Human

Specificity

Human

Clone

CBXC-0743

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Buffer containing stabilizer

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Killer Cell Lectin Like Receptor C2

Introduction

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.

Entrez Gene ID

3822

UniProt ID

P26717

Alternative Names

Killer Cell Lectin Like Receptor C2; Killer Cell Lectin-Like Receptor Subfamily C, Member 2; CD159 Antigen-Like Family Member C; NKG2-C-Activating NK Receptor; NK Cell Receptor C; NKG2C;

Function

Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159).
Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657).
Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell mediated immunityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Stimulatory C-type lectin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-70
Helical: 71-93
Extracellular: 94-231

References

Jaiswal, S. R., Arunachalam, J., Bhardwaj, A., Saifullah, A., Lakhchaura, R., Soni, M., ... & Chakrabarti, S. (2022). Impact of adaptive natural killer cells, KLRC2 genotype and cytomegalovirus reactivation on late mortality in patients with severe COVID‐19 lung disease. Clinical & Translational Immunology, 11(1), e1359.

Vietzen, H., Zoufaly, A., Traugott, M., Aberle, J., Aberle, S. W., & Puchhammer-Stöckl, E. (2021). Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19. Genetics in Medicine, 23(5), 963-967.

Asenjo, J., Muntasell, A., López‐Botet, M., Moraru, M., & Vilches, C. (2021). Complete genomic characterization of a new KLRC2 allele, NKG2C* 03. Hla, 98(3), 259.

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K., & Toda, M. (2019). Identification of KLRC2 as a candidate marker for brain tumor-initiating cells. Neurological research, 41(11), 1043-1049.

Ram, D. R., Manickam, C., Hueber, B., Itell, H. L., Permar, S. R., Varner, V., & Reeves, R. K. (2018). Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. PLoS Pathogens, 14(5), e1007104.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-KLRC2 Recombinant Antibody (CBWJN-0912)

Mouse Anti-KLRC2 Recombinant Antibody (CBWJN-0911)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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