Human Recombinant KLRC2 protein, ECD, hFc Tag (V2LY-0526-LY5195)

Name: Human Recombinant KLRC2 protein, ECD, hFc Tag
SKU: V2LY-0526-LY5195
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant KLRC2 protein, ECD, hFc Tag consist of Amino Acid: 94-231 and predicts a molecular mass of 42.4 kDa.

Molecule Mass

42.4 kDa

Protein Domain

ECD

Sequence

Amino Acid: 94-231

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glycerol, GSH

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Killer Cell Lectin Like Receptor C2

Function

Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159).
Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657).
Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674).

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell mediated immunityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Stimulatory C-type lectin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-70
Helical: 71-93
Extracellular: 94-231

Jaiswal, S. R., Arunachalam, J., Bhardwaj, A., Saifullah, A., Lakhchaura, R., Soni, M., ... & Chakrabarti, S. (2022). Impact of adaptive natural killer cells, KLRC2 genotype and cytomegalovirus reactivation on late mortality in patients with severe COVID‐19 lung disease. Clinical & Translational Immunology, 11(1), e1359.

Vietzen, H., Zoufaly, A., Traugott, M., Aberle, J., Aberle, S. W., & Puchhammer-Stöckl, E. (2021). Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19. Genetics in Medicine, 23(5), 963-967.

Asenjo, J., Muntasell, A., López‐Botet, M., Moraru, M., & Vilches, C. (2021). Complete genomic characterization of a new KLRC2 allele, NKG2C* 03. Hla, 98(3), 259.

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K., & Toda, M. (2019). Identification of KLRC2 as a candidate marker for brain tumor-initiating cells. Neurological research, 41(11), 1043-1049.

Ram, D. R., Manickam, C., Hueber, B., Itell, H. L., Permar, S. R., Varner, V., & Reeves, R. K. (2018). Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. PLoS Pathogens, 14(5), e1007104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLRC2 protein, ECD, His Tag (CAT#: V2LY-0526-LY5196)

Human KLRC2 ELISA Kit (CAT#: V2LY-0626-LY4958)

Related Products

Mouse Anti-KLRC2 Recombinant Antibody (CBWJN-0911) (CAT#: CBMAB-N0046-WJ)

Human KLRC2 ELISA Kit (CAT#: V2LY-0626-LY4958)

Human Recombinant KLRC2 protein, ECD, His Tag (CAT#: V2LY-0526-LY5196)

Mouse Anti-KLRC2 Recombinant Antibody (CBWJN-0912) (CAT#: CBMAB-N0047-WJ)

Human Anti-KLRC2 Recombinant Antibody (CBXC-0743) (CAT#: CBMAB-C1857-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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