Human KLRC2 ELISA Kit (V2LY-0626-LY4958)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.019 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
26.1 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Killer Cell Lectin Like Receptor C2
Function
Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159).
Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657).
Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell mediated immunityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Stimulatory C-type lectin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-70
Helical: 71-93
Extracellular: 94-231

Jaiswal, S. R., Arunachalam, J., Bhardwaj, A., Saifullah, A., Lakhchaura, R., Soni, M., ... & Chakrabarti, S. (2022). Impact of adaptive natural killer cells, KLRC2 genotype and cytomegalovirus reactivation on late mortality in patients with severe COVID‐19 lung disease. Clinical & Translational Immunology, 11(1), e1359.

Vietzen, H., Zoufaly, A., Traugott, M., Aberle, J., Aberle, S. W., & Puchhammer-Stöckl, E. (2021). Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19. Genetics in Medicine, 23(5), 963-967.

Asenjo, J., Muntasell, A., López‐Botet, M., Moraru, M., & Vilches, C. (2021). Complete genomic characterization of a new KLRC2 allele, NKG2C* 03. Hla, 98(3), 259.

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K., & Toda, M. (2019). Identification of KLRC2 as a candidate marker for brain tumor-initiating cells. Neurological research, 41(11), 1043-1049.

Ram, D. R., Manickam, C., Hueber, B., Itell, H. L., Permar, S. R., Varner, V., & Reeves, R. K. (2018). Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. PLoS Pathogens, 14(5), e1007104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLRC2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5195)

Human Recombinant KLRC2 protein, ECD, His Tag (CAT#: V2LY-0526-LY5196)

Related Products

Mouse Anti-KLRC2 Recombinant Antibody (CBWJN-0912) (CAT#: CBMAB-N0047-WJ)

Mouse Anti-KLRC2 Recombinant Antibody (CBWJN-0911) (CAT#: CBMAB-N0046-WJ)

Human Recombinant KLRC2 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5195)

Human Recombinant KLRC2 protein, ECD, His Tag (CAT#: V2LY-0526-LY5196)

Human Anti-KLRC2 Recombinant Antibody (CBXC-0743) (CAT#: CBMAB-C1857-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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