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Rabbit Anti-KLRG1 Recombinant Antibody (CBLY1-129) (CBMAB-K1416-LY)

This product is antibody recognizes KLRG1. The antibody CBLY1-129 immunoassay techniques such as: WB.
See all KLRG1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLY1-129
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Lectin Like Receptor G1
Introduction
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]
Entrez Gene ID
Human10219
Mouse50928
Rat58975
UniProt ID
HumanQ96E93
MouseO88713
RatQ64335
Function
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIEA:UniProtKB-KW
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-38
Helical: 39-59
Extracellular: 60-195

Assatova, B., Trevisani, C., Willim, R., Duffy, J., Louissaint, A., Kim, W. S., ... & Jain, S. (2022). KLRG1 Depletion Is a Novel Therapeutic Strategy for Patients with Mature T and NK/T-Cell Lymphomas. Blood, 140(Supplement 1), 2253-2255.

Bag, A. K., Schultz, A. R., Goala, P., Karreth, F. A., & Adeegbe, D. O. (2021). Investigating the role of KLRG1 in regulatory T-cells and implications for anti-tumor immunity in Non-small Cell Lung Cancer. The Journal of Immunology, 206(1_Supplement), 57-02.

Yang, X., Zheng, Y., Han, Z., & Zhang, X. (2021). Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy. BMC cancer, 21, 1-16.

Tata, A., Dodard, G., Fugère, C., Leget, C., Ors, M., Rossi, B., ... & Brossay, L. (2021). Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers. Oncoimmunology, 10(1), 1933808.

Bottois, H., Ngollo, M., Hammoudi, N., Courau, T., Bonnereau, J., Chardiny, V., ... & Le Bourhis, L. (2020). Klrg1 and CD103 expressions define distinct intestinal tissue-resident memory CD8 T cell subsets modulated in Crohn's disease. Frontiers in Immunology, 11, 896.

Bull, N. C., Stylianou, E., Kaveh, D. A., Pinpathomrat, N., Pasricha, J., Harrington-Kandt, R., ... & McShane, H. (2019). Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells. Mucosal immunology, 12(2), 555-564.

Remmerswaal, E. B., Hombrink, P., Nota, B., Pircher, H., Ten Berge, I. J., van Lier, R. A., & van Aalderen, M. C. (2019). Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8+ T‐cell populations in humans. European Journal of Immunology, 49(5), 694-708.

Herndler-Brandstetter, D., Ishigame, H., Shinnakasu, R., Plajer, V., Stecher, C., Zhao, J., ... & Flavell, R. A. (2018). KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity. Immunity, 48(4), 716-729.

Hu, Z., Zhao, H. M., Li, C. L., Liu, X. H., Barkan, D., Lowrie, D. B., ... & Fan, X. Y. (2018). The role of KLRG1 in human CD4+ T-cell immunity against tuberculosis. The Journal of Infectious Diseases, 217(9), 1491-1503.

Kadel, S., Ainsua-Enrich, E., Hatipoglu, I., Turner, S., Singh, S., Khan, S., & Kovats, S. (2018). A major population of functional KLRG1–ILC2s in female lungs contributes to a sex bias in ILC2 numbers. Immunohorizons, 2(2), 74-86.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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