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Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177)


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Tested Data
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in ELISA
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in ELISA
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in WB
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in WB
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in WB
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in WB
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in IF
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in IF
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in FC
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in FC
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in IHC
Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3627
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human KMT2C (AA: 1-205) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
58508
UniProt ID
Q8NEZ4
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738).
Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:24081332, PubMed:22266653).
Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332).
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone H3-K4 monomethylationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Kleefstra syndrome 2 (KLEFS2):
A form of Kleefstra syndrome, an autosomal dominant disease characterized by variable mental retardation, psychomotor developmental delay, seizures, behavioral abnormalities, and facial dysmorphisms.
More Infomation

Na, F., Pan, X., Chen, J., Chen, X., Wang, M., Chi, P., ... & Chen, C. (2022). KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming. Nature cancer, 3(6), 753-767.

Limberger, T., Schlederer, M., Trachtová, K., Garces de los Fayos Alonso, I., Yang, J., Högler, S., ... & Kenner, L. (2022). KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis. Molecular Cancer, 21(1), 89.

Liu, X., Qiu, R., Xu, M., Meng, M., Zhao, S., Ji, J., & Yang, Y. (2021). KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer. Breast Cancer Research and Treatment, 189, 347-361.

Mastoraki, S., Balgkouranidou, I., Tsaroucha, E., Klinakis, A., Georgoulias, V., & Lianidou, E. (2021). KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancer. Molecular Oncology, 15(9), 2412-2422.

Lavery, W. J., Barski, A., Wiley, S., Schorry, E. K., & Lindsley, A. W. (2020). KMT2C/D COMPASS complex-associated diseases [K CD COM-ADs]: an emerging class of congenital regulopathies. Clinical epigenetics, 12, 1-20.

Larsson, C., Cordeddu, L., Siggens, L., Pandzic, T., Kundu, S., He, L., ... & Sjöblom, T. (2020). Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression. Clinical Epigenetics, 12(1), 1-12.

Chen, X., Zhang, G., Chen, B., Wang, Y., Guo, L., Cao, L., ... & Liao, N. (2019). Association between histone lysine methyltransferase KMT2C mutation and clinicopathological factors in breast cancer. Biomedicine & Pharmacotherapy, 116, 108997.

Fagan, R. J., & Dingwall, A. K. (2019). COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer. Cancer letters, 458, 56-65.

Cho, S. J., Yoon, C., Lee, J. H., Chang, K. K., Lin, J. X., Kim, Y. H., ... & Yoon, S. S. (2018). KMT2C mutations in diffuse-type gastric adenocarcinoma promote epithelial-to-mesenchymal transition. Clinical Cancer Research, 24(24), 6556-6569.

Gala, K., Li, Q., Sinha, A., Razavi, P., Dorso, M., Sanchez-Vega, F., ... & Chandarlapaty, S. (2018). KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene, 37(34), 4692-4710.

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For research use only. Not intended for any clinical use.

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