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Rabbit Anti-KMT2C Recombinant Antibody (D1S1V) (CBMAB-CP1556-LY)

The product is antibody recognizes KMT2C. The antibody D1S1V immunoassay techniques such as: WB.
See all KMT2C antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D1S1V
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala2110 of human MLL3 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysine Methyltransferase 2C
Introduction
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
58508
UniProt ID
Q8NEZ4
Alternative Names
Lysine Methyltransferase 2C; Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 3; Lysine (K)-Specific Methyltransferase 2C; Homologous To ALR Protein; MLL3; HALR; Histone-Lysine N-Methyltransferase; H3 Lysine-4 Specific; Myeloid/Lymphoid Or Mixed-Lineage Leukemia 3;
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738).
Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:24081332, PubMed:22266653).
Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332).
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone H3-K4 monomethylationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Kleefstra syndrome 2 (KLEFS2):
A form of Kleefstra syndrome, an autosomal dominant disease characterized by variable mental retardation, psychomotor developmental delay, seizures, behavioral abnormalities, and facial dysmorphisms.

Na, F., Pan, X., Chen, J., Chen, X., Wang, M., Chi, P., ... & Chen, C. (2022). KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming. Nature cancer, 3(6), 753-767.

Limberger, T., Schlederer, M., Trachtová, K., Garces de los Fayos Alonso, I., Yang, J., Högler, S., ... & Kenner, L. (2022). KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis. Molecular Cancer, 21(1), 89.

Liu, X., Qiu, R., Xu, M., Meng, M., Zhao, S., Ji, J., & Yang, Y. (2021). KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer. Breast Cancer Research and Treatment, 189, 347-361.

Mastoraki, S., Balgkouranidou, I., Tsaroucha, E., Klinakis, A., Georgoulias, V., & Lianidou, E. (2021). KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancer. Molecular Oncology, 15(9), 2412-2422.

Lavery, W. J., Barski, A., Wiley, S., Schorry, E. K., & Lindsley, A. W. (2020). KMT2C/D COMPASS complex-associated diseases [K CD COM-ADs]: an emerging class of congenital regulopathies. Clinical epigenetics, 12, 1-20.

Larsson, C., Cordeddu, L., Siggens, L., Pandzic, T., Kundu, S., He, L., ... & Sjöblom, T. (2020). Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression. Clinical Epigenetics, 12(1), 1-12.

Chen, X., Zhang, G., Chen, B., Wang, Y., Guo, L., Cao, L., ... & Liao, N. (2019). Association between histone lysine methyltransferase KMT2C mutation and clinicopathological factors in breast cancer. Biomedicine & Pharmacotherapy, 116, 108997.

Fagan, R. J., & Dingwall, A. K. (2019). COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer. Cancer letters, 458, 56-65.

Cho, S. J., Yoon, C., Lee, J. H., Chang, K. K., Lin, J. X., Kim, Y. H., ... & Yoon, S. S. (2018). KMT2C mutations in diffuse-type gastric adenocarcinoma promote epithelial-to-mesenchymal transition. Clinical Cancer Research, 24(24), 6556-6569.

Gala, K., Li, Q., Sinha, A., Razavi, P., Dorso, M., Sanchez-Vega, F., ... & Chandarlapaty, S. (2018). KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene, 37(34), 4692-4710.

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For research use only. Not intended for any clinical use.

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