KMT2C

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Full Name
Lysine Methyltransferase 2C
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738).
Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:24081332, PubMed:22266653).
Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332).
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone H3-K4 monomethylationManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Kleefstra syndrome 2 (KLEFS2):
A form of Kleefstra syndrome, an autosomal dominant disease characterized by variable mental retardation, psychomotor developmental delay, seizures, behavioral abnormalities, and facial dysmorphisms.
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Anti-KMT2C antibodies

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Rabbit Anti-KMT2C Recombinant Antibody (D1S1V) (CBMAB-CP1556-LY)

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Target: KMT2C
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1S1V
Application*: WB
Datasheet SDS

Mouse Anti-KMT2C Recombinant Antibody (CBFYM-1193) (CBMAB-M1350-FY)

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Target: KMT2C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1193
Application*: WB, E
Datasheet SDS

Mouse Anti-KMT2C Recombinant Antibody (CBT2314) (V2LY-0625-LY1178)

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Target: KMT2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2314
Application*: F
Datasheet SDS

Mouse Anti-KMT2C Recombinant Antibody (CBT3627) (V2LY-0625-LY1177)

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Target: KMT2C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3627
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-KMT2C Recombinant Antibody (1686CT202.60.69) (CBMAB-K1430-LY)

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Target: KMT2C
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1686CT202.60.69
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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