Mouse Anti-KRT13 Recombinant Antibody (CBT3969) (V2LY-0625-LY2737)

Name: Mouse Anti-KRT13 Recombinant Antibody (CBT3969)
SKU: V2LY-0625-LY2737
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT3969

Antibody Isotype

IgG1

Application

WB, FC

Basic Information

Immunogen

Purified recombinant fragment of human KRT13 (AA: 143-295) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Keratin 13

Entrez Gene ID

3860

UniProt ID

P13646

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytosol
Extracellular exosome
Intermediate filament cytoskeleton
Keratin filament
Nucleus

Involvement in disease

White sponge nevus 2 (WSN2):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

PTM

O-glycosylated; glycans consist of single N-acetylglucosamine residues.

More Infomation

References

Yin, L., Li, Q., Mrdenovic, S., Chu, G. C. Y., Wu, B. J., Bu, H., ... & Chung, L. W. (2022). KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway. Breast Cancer Research, 24(1), 1-13.

Simonson, L., Vold, S., Mowers, C., Massey, R. J., Ong, I. M., Longley, B. J., & Chang, H. (2020). Keratin 13 deficiency causes white sponge nevus in mice. Developmental biology, 468(1-2), 146-153.

Yin, L., Chu, G. C. Y., Li, Q., Yin, L., Lewis, M., Tighiouart, M., ... & Zhau, H. E. (2018). KRT13 promotes stemness and drives metastasis in breast cancer through direct interaction with plakoglobin-desmoplakin complexes regulating c-Myc signaling pathway. Cancer Research, 78(13_Supplement), 5002-5002.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Hatta, M., Miyake, Y., Uchida, K., & Yamazaki, J. (2018). Keratin 13 gene is epigenetically suppressed during transforming growth factor-β1-induced epithelial-mesenchymal transition in a human keratinocyte cell line. Biochemical and biophysical research communications, 496(2), 381-386.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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