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Mouse Anti-KRT13 Recombinant Antibody (Ks 13.1) (CBMAB-C5300WJ)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
Ks 13.1
Application
IF, IHC-Fr, IHC-P, WB
Immunogen
Cytokeratin 13 antibody was raised in mouse using cytokeratin 13 purified from human esophagus as the immunogen
Specificity
Cattle, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.5% BSA in PBS buffer, pH 7.4
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Keratin 13
Introduction
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Rat287699
Cattle100296555
UniProt ID
RatQ6IFV4
CattleA0A3Q1LJB2
Alternative Names
Keratin 13; Keratin, Type I Cytoskeletal 13; Keratin 13, Type I; Cytokeratin 13; CK-13; K13;
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament cytoskeleton
Keratin filament
Nucleus
Involvement in disease
White sponge nevus 2 (WSN2):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
PTM
O-glycosylated; glycans consist of single N-acetylglucosamine residues.

Yin, L., Li, Q., Mrdenovic, S., Chu, G. C. Y., Wu, B. J., Bu, H., ... & Chung, L. W. (2022). KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway. Breast Cancer Research, 24(1), 1-13.

Simonson, L., Vold, S., Mowers, C., Massey, R. J., Ong, I. M., Longley, B. J., & Chang, H. (2020). Keratin 13 deficiency causes white sponge nevus in mice. Developmental biology, 468(1-2), 146-153.

Yin, L., Chu, G. C. Y., Li, Q., Yin, L., Lewis, M., Tighiouart, M., ... & Zhau, H. E. (2018). KRT13 promotes stemness and drives metastasis in breast cancer through direct interaction with plakoglobin-desmoplakin complexes regulating c-Myc signaling pathway. Cancer Research, 78(13_Supplement), 5002-5002.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Hatta, M., Miyake, Y., Uchida, K., & Yamazaki, J. (2018). Keratin 13 gene is epigenetically suppressed during transforming growth factor-β1-induced epithelial-mesenchymal transition in a human keratinocyte cell line. Biochemical and biophysical research communications, 496(2), 381-386.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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