Mouse Anti-KRT6C (C-terminus) Recombinant Antibody (CBYY-C2618) (CBMAB-C4059-YY)

Name: Mouse Anti-KRT6C (C-terminus) Recombinant Antibody (CBYY-C2618)
SKU: CBMAB-C4059-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C2618

Application

IHC

Immunogen

Synthetic peptide derived from C-terminus of human cytokeratin 6

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Tissue culture supernatant

Preservative

50% glycerol

Concentration

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

C-terminus

More Infomation

Target

Full Name

Keratin 6C

Entrez Gene ID

286887

UniProt ID

P48668

Alternative Names

K6E; KRT6E; PPKNEFD

Biological Process

Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytosol
Extracellular exosome
Intermediate filament
Keratin filament

Involvement in disease

Palmoplantar keratoderma, non-epidermolytic, focal or diffuse (PPKNEFD):
A dermatological disorder characterized by non-epidermolytic abnormal thickening of the skin on the palms and soles. Diffuse palmoplantar keratoderma is characterized by uniform involvement of the palmoplantar surface, while the focal form consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction.

Li, P., Qi, J., Zhong, Y., Ding, A., & Xiao, H. (2023). Proteomic profiling reveals KRT6C as a probable hereterodimer partner for KRT9: New insights into re-classifying epidermolytic palmoplantar keratoderma (EPPK) and a milder form of pachyonychia congenita (PC-K6c) as a group of genetic cutaneous disorders. Journal of Proteomics, 287, 104971.

Jiang, Z., Hou, Z., Liu, W., Yu, Z., Liang, Z., & Chen, S. (2021). Circ-Keratin 6c promotes malignant progression and immune evasion of colorectal cancer through microRNA-485-3p/programmed cell death receptor ligand 1 axis. Journal of Pharmacology and Experimental Therapeutics, 377(3), 358-367.

Hu, H. B., Yang, X. P., Zhou, P. X., Yang, X. A., & Yin, B. (2020). High expression of keratin 6C is associated with poor prognosis and accelerates cancer proliferation and migration by modulating epithelial–mesenchymal transition in lung adenocarcinoma. Genes & genomics, 42, 179-188.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-KRT6C Recombinant Antibody (CBWJC-4073) (CAT#: CBMAB-C5404WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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