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Mouse Anti-KRT6C Recombinant Antibody (CBYY-C2620) (CBMAB-C4061-YY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBYY-C2620
Application
IHC, WB
Immunogen
Cytokeratin 6 of human callus cytoskeletal preparation
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
0.05 mg/mL
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Keratin 6C
Entrez Gene ID
286887
UniProt ID
P48668
Alternative Names
K6E; KRT6E; PPKNEFD
Biological Process
Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Keratin filament
Involvement in disease
Palmoplantar keratoderma, non-epidermolytic, focal or diffuse (PPKNEFD):
A dermatological disorder characterized by non-epidermolytic abnormal thickening of the skin on the palms and soles. Diffuse palmoplantar keratoderma is characterized by uniform involvement of the palmoplantar surface, while the focal form consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction.

Li, P., Qi, J., Zhong, Y., Ding, A., & Xiao, H. (2023). Proteomic profiling reveals KRT6C as a probable hereterodimer partner for KRT9: New insights into re-classifying epidermolytic palmoplantar keratoderma (EPPK) and a milder form of pachyonychia congenita (PC-K6c) as a group of genetic cutaneous disorders. Journal of Proteomics, 287, 104971.

Jiang, Z., Hou, Z., Liu, W., Yu, Z., Liang, Z., & Chen, S. (2021). Circ-Keratin 6c promotes malignant progression and immune evasion of colorectal cancer through microRNA-485-3p/programmed cell death receptor ligand 1 axis. Journal of Pharmacology and Experimental Therapeutics, 377(3), 358-367.

Hu, H. B., Yang, X. P., Zhou, P. X., Yang, X. A., & Yin, B. (2020). High expression of keratin 6C is associated with poor prognosis and accelerates cancer proliferation and migration by modulating epithelial–mesenchymal transition in lung adenocarcinoma. Genes & genomics, 42, 179-188.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-KRT6C Recombinant Antibody (CBYY-C2617) (CAT#: CBMAB-C4058-YY)

Mouse Anti-KRT6C Recombinant Antibody (CBWJC-4073) (CAT#: CBMAB-C5404WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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