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Mouse Anti-KYNU Recombinant Antibody (1G2) (CBMAB-K2092-LY)

This product is antibody recognizes KYNU. The antibody 1G2 immunoassay techniques such as: ELISA, WB.
See all KYNU antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G2
Antibody Isotype
IgG2a, λ
Application
ELISA, WB

Basic Information

Immunogen
KYNU (NP_003928, 2 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG2a, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kynureninase (L-kynurenine hydrolase)
Introduction
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Entrez Gene ID
8942
UniProt ID
Q16719
Alternative Names
Kynureninase; L-Kynurenine Hydrolase; EC 3.7.1.3; Kynureninase (L-Kynurenine Hydrolase); KYNUU; VCRL2;
Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Biological Process
de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
Anthranilate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine catabolic processIEA:UniProtKB-UniPathway
NAD biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Quinolinate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to interferon-gammaManual Assertion Based On ExperimentIDA:UniProtKB
Response to vitamin B6Manual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic process to kynurenineManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Hydroxykynureninuria (HYXKY):
An inborn error of amino acid metabolism characterized by massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid. Affected individuals manifest renal tubular dysfunction, metabolic acidosis, psychomotor retardation, non-progressive encephalopathy, and muscular hypertonia.
Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2):
An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects.

Shi, Y., Luo, S., Zhai, J., & Chen, Y. (2024). A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1870(2), 166929.

León-Letelier, R. A., Abdel Sater, A. H., Chen, Y., Park, S., Wu, R., Irajizad, E., ... & Fahrmann, J. F. (2023). Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis. Cancers, 15(3), 834.

Fahrmann, J. F., Tanaka, I., Irajizad, E., Mao, X., Dennison, J. B., Murage, E., ... & Ostrin, E. J. (2022). Mutational activation of the NRF2 pathway upregulates kynureninase resulting in tumor immunosuppression and poor outcome in lung adenocarcinoma. Cancers, 14(10), 2543.

Yang, Q., Hao, J., Chi, M., Wang, Y., Xin, B., Huang, J., ... & Guo, C. (2022). Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism. Oncoimmunology, 11(1), 2055703.

Wang, M., Wang, Y., Zhang, M., Duan, Q., Chen, C., Sun, Q., ... & Shao, Y. (2022). Kynureninase contributes to the pathogenesis of psoriasis through pro‐inflammatory effect. Journal of Cellular Physiology, 237(1), 1044-1056.

Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, S. A., ... & Ketelhuth, D. F. J. (2021). Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans. Journal of Internal Medicine, 289(1), 53-68.

Jovanovic, F., Candido, K. D., & Knezevic, N. N. (2020). The role of the kynurenine signaling pathway in different chronic pain conditions and potential use of therapeutic agents. International journal of molecular sciences, 21(17), 6045.

Liu, Y., Feng, X., Lai, J., Yi, W., Yang, J., Du, T., ... & Xiao, Y. (2019). A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer. Journal of cellular and molecular medicine, 23(10), 6700-6707.

Boros, F. A., Bohár, Z., & Vécsei, L. (2018). Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases. Mutation Research/Reviews in Mutation Research, 776, 32-45.

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For research use only. Not intended for any clinical use.

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