KYNU

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

kynureninase (L-kynurenine hydrolase)

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
Anthranilate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine catabolic processIEA:UniProtKB-UniPathway
NAD biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Quinolinate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to interferon-gammaManual Assertion Based On ExperimentIDA:UniProtKB
Response to vitamin B6Manual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic process to kynurenineManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm, cytosol

Hydroxykynureninuria (HYXKY):
An inborn error of amino acid metabolism characterized by massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid. Affected individuals manifest renal tubular dysfunction, metabolic acidosis, psychomotor retardation, non-progressive encephalopathy, and muscular hypertonia.
Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2):
An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects.