KYNU

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
kynureninase (L-kynurenine hydrolase)
Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Biological Process
de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
Anthranilate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine catabolic processIEA:UniProtKB-UniPathway
NAD biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Quinolinate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to interferon-gammaManual Assertion Based On ExperimentIDA:UniProtKB
Response to vitamin B6Manual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic process to kynurenineManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Hydroxykynureninuria (HYXKY):
An inborn error of amino acid metabolism characterized by massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid. Affected individuals manifest renal tubular dysfunction, metabolic acidosis, psychomotor retardation, non-progressive encephalopathy, and muscular hypertonia.
Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2):
An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects.
View more

Anti-KYNU antibodies

+ Filters
Loading...

Rat Anti-KYNU Recombinant Antibody (771312) (CBMAB-K2096-LY)

Go to compareCompare
Target: KYNU
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 771312
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-KYNU Recombinant Antibody (1G2) (CBMAB-K2092-LY)

Go to compareCompare
Target: KYNU
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 1G2
Application*: E, WB
Datasheet SDS

Rat Anti-KYNU Recombinant Antibody (15H82) (CBMAB-K2090-LY)

Go to compareCompare
Target: KYNU
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 15H82
Application*: IH, WB
Datasheet SDS

Mouse Anti-KYNU Recombinant Antibody (CBYCL-134) (CBMAB-L0035-YC)

Go to compareCompare
Target: KYNU
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCL-134
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-KYNU Recombinant Antibody (5E4) (CBMAB-K2095-LY)

Go to compareCompare
Target: KYNU
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E4
Application*: P, WB
Datasheet SDS

Mouse Anti-KYNU Recombinant Antibody (1H1) (CBMAB-K2093-LY)

Go to compareCompare
Target: KYNU
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1H1
Application*: IH
Datasheet SDS

Mouse Anti-KYNU Recombinant Antibody (1F1) (CBMAB-K2091-LY)

Go to compareCompare
Target: KYNU
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1F1
Application*: WB
Datasheet SDS

Mouse Anti-KYNU Recombinant Antibody (12K123) (CBMAB-K2089-LY)

Go to compareCompare
Target: KYNU
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12K123
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry