Human Recombinant KYNU protein, His Tag (V2LY-0526-LY5223)

Name: Human Recombinant KYNU protein, His Tag
SKU: V2LY-0526-LY5223
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant KYNU protein, His Tag consist of Amino Acid: 1-465 and predicts a molecular mass of 53.80 kDa.

Molecule Mass

53.80 kDa

Sequence

Amino Acid: 1-465

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>92% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

kynureninase (L-kynurenine hydrolase)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Biological Process

de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
Anthranilate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine catabolic processIEA:UniProtKB-UniPathway
NAD biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Quinolinate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to interferon-gammaManual Assertion Based On ExperimentIDA:UniProtKB
Response to vitamin B6Manual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Tryptophan catabolic process to kynurenineManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytosol

Involvement in disease

Hydroxykynureninuria (HYXKY):
An inborn error of amino acid metabolism characterized by massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid. Affected individuals manifest renal tubular dysfunction, metabolic acidosis, psychomotor retardation, non-progressive encephalopathy, and muscular hypertonia.
Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2):
An autosomal recessive congenital malformation syndrome characterized by vertebral segmentation abnormalities, congenital cardiac defects, renal defects, and distal mild limb defects.

Shi, Y., Luo, S., Zhai, J., & Chen, Y. (2024). A novel causative role of imbalanced kynurenine pathway in ulcerative colitis: Upregulation of KMO and KYNU promotes intestinal inflammation. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1870(2), 166929.

León-Letelier, R. A., Abdel Sater, A. H., Chen, Y., Park, S., Wu, R., Irajizad, E., ... & Fahrmann, J. F. (2023). Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis. Cancers, 15(3), 834.

Fahrmann, J. F., Tanaka, I., Irajizad, E., Mao, X., Dennison, J. B., Murage, E., ... & Ostrin, E. J. (2022). Mutational activation of the NRF2 pathway upregulates kynureninase resulting in tumor immunosuppression and poor outcome in lung adenocarcinoma. Cancers, 14(10), 2543.

Yang, Q., Hao, J., Chi, M., Wang, Y., Xin, B., Huang, J., ... & Guo, C. (2022). Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism. Oncoimmunology, 11(1), 2055703.

Wang, M., Wang, Y., Zhang, M., Duan, Q., Chen, C., Sun, Q., ... & Shao, Y. (2022). Kynureninase contributes to the pathogenesis of psoriasis through pro‐inflammatory effect. Journal of Cellular Physiology, 237(1), 1044-1056.

Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, S. A., ... & Ketelhuth, D. F. J. (2021). Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans. Journal of Internal Medicine, 289(1), 53-68.

Jovanovic, F., Candido, K. D., & Knezevic, N. N. (2020). The role of the kynurenine signaling pathway in different chronic pain conditions and potential use of therapeutic agents. International journal of molecular sciences, 21(17), 6045.

Liu, Y., Feng, X., Lai, J., Yi, W., Yang, J., Du, T., ... & Xiao, Y. (2019). A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer. Journal of cellular and molecular medicine, 23(10), 6700-6707.

Boros, F. A., Bohár, Z., & Vécsei, L. (2018). Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases. Mutation Research/Reviews in Mutation Research, 776, 32-45.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant KYNU protein, His Tag (CAT#: V2LY-0526-LY8596)

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Mouse Recombinant KYNU protein, His Tag (CAT#: V2LY-0526-LY8596)

Isotype control

For research use only. Not intended for any clinical use.

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