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Mouse Anti-LAMP3 Recombinant Antibody (104G4) (CBMAB-D2094-YC)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
104G4
Application
FC, IHC-Fr, ICC, IF, IHC-P
Immunogen
LAMP3 was used as immunogen
Specificity
Human, Sheep
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Lysosomal Associated Membrane Protein 3
Introduction
Endritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses.
Entrez Gene ID
Human27074
Sheep101103444
UniProt ID
HumanQ9UQV4
SheepW5QHK0
Alternative Names
LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP
Function
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212).
Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718).
Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532).
May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752).
(Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection.
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
(Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of viral life cycleManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Response to interferon-alphaManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Cell surface
Lysosome membrane
Cytoplasmic vesicle membrane
Early endosome membrane
During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752).
Detected on lysosomes in mature dendritic cells (PubMed:9768752).
Topology
Lumenal: 28-381
Helical: 382-402
Cytoplasmic: 403-416

Wang, Z., Wang, X., Jin, R., Liu, F., Rao, H., Wei, L., ... & Feng, B. (2023). LAMP3 expression in the liver is involved in T cell activation and adaptive immune regulation in hepatitis B virus infection. Frontiers in Immunology, 14, 1127572.

Tanaka, T., Warner, B. M., Michael, D. G., Nakamura, H., Odani, T., Yin, H., ... & Chiorini, J. A. (2022). LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization. Autophagy, 18(7), 1629-1647.

Nakamura, H., Tanaka, T., Zheng, C., Afione, S. A., Warner, B. M., Noguchi, M., ... & Chiorini, J. A. (2022). Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy. Scientific Reports, 12(1), 18570.

Sun, Q., Wang, F., Chen, Q., Sarid, R., Li, X., & Kuang, E. (2022). Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus. Journal of Virology, 96(23), e01456-22.

Huang, F., Ma, G., Zhou, X., Zhu, X., Yu, X., Ding, F., ... & Liu, Z. (2020). Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma. Cancer Letters, 479, 100-111.

Tanaka, T., Warner, B. M., Odani, T., Ji, Y., Mo, Y. Q., Nakamura, H., ... & Chiorini, J. A. (2020). LAMP3 induces apoptosis and autoantigen release in Sjögren’s syndrome patients. Scientific Reports, 10(1), 15169.

Burton, T. D., Fedele, A. O., Xie, J., Sandeman, L. Y., & Proud, C. G. (2020). The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4. Journal of Biological Chemistry, 295(21), 7418-7430.

Nishimura, J., Tanaka, H., Yamakoshi, Y., Hiramatsu, S., Tamura, T., Toyokawa, T., ... & Ohira, M. (2019). Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma. Esophagus, 16, 333-344.

Yang, C., Shen, S., Zheng, X., Ye, K., Sun, Y., Lu, Y., & Ge, H. (2019). Long noncoding RNA HAGLR acts as a microRNA‐143‐5p sponge to regulate epithelial‐mesenchymal transition and metastatic potential in esophageal cancer by regulating LAMP3. The FASEB Journal, 33(9), 10490-10504.

Liao, X., Song, L., Zhang, L., Wang, H., Tong, Q., Xu, J., ... & Zheng, H. (2018). LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. Molecular and cellular endocrinology, 470, 160-167.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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