LAMP3
LAMP3 (Lysosomal Associated Membrane Protein 3) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is CD68.
Full Name
Lysosomal Associated Membrane Protein 3
Function
Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212).
Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718).
Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532).
May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752).
(Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection.
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
(Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.
Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718).
Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532).
May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752).
(Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection.
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
(Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of viral life cycleManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Response to interferon-alphaManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of viral life cycleManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Response to interferon-alphaManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Cell surface
Lysosome membrane
Cytoplasmic vesicle membrane
Early endosome membrane
During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752).
Detected on lysosomes in mature dendritic cells (PubMed:9768752).
Lysosome membrane
Cytoplasmic vesicle membrane
Early endosome membrane
During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752).
Detected on lysosomes in mature dendritic cells (PubMed:9768752).
Topology
Lumenal: 28-381
Helical: 382-402
Cytoplasmic: 403-416
Helical: 382-402
Cytoplasmic: 403-416
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Anti-LAMP3 antibodies
+ Filters
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CompareTarget: LAMP3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Dog, Cat, Sheep
Clone: 1010E1.01
Application*: IH, P, C
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H44
Application*: WB, B, N
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A866
Application*: ELISA, IHC, WB
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4116
Application*: F
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: L3P2H10
Application*: E, IH, WB
Target: LAMP3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0793
Application*: F
Target: LAMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2919
Application*: E, ED
Target: LAMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2918
Application*: IC, IF
Target: LAMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 020
Application*: EC
Target: LAMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 007
Application*: IC/IF, IF
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJL-1173
Application*: IH, WB
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: LAMP3/529
Application*: F, IF
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F1G10F2
Application*: E
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1172
Application*: WB
Target: LAMP3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1171
Application*: E
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 13A205
Application*: IH, WB
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: 208B5
Application*: F, IH, P, C
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 109G3
Application*: F, IH, P, C
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Sheep
Clone: 104G4
Application*: F, C, IC, IF, P
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: L3P2H10/E3
Application*: WB, E, IH
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4357
Application*: F
Target: LAMP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2636
Application*: E
Target: LAMP3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 1006F7.05
Application*: F, C, IC, IF, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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