Mouse Anti-LAMP3 Recombinant Antibody (A866) (CBMAB-AP4229LY)

Name: Mouse Anti-LAMP3 Recombinant Antibody (A866)
SKU: CBMAB-AP4229LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A866

Application

ELISA, IHC, WB

Immunogen

Ovalbumin-conjugated synthetic peptide - RCQSSGYQRI

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Lysosomal Associated Membrane Protein 3

Entrez Gene ID

27074

UniProt ID

Q9UQV4

Function

152684

Biological Process

Adaptive immune responseIEA:UniProtKB-KW
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of viral life cycleManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Response to interferon-alphaManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL

Cellular Location

Cell surface
Lysosome membrane
Cytoplasmic vesicle membrane
Early endosome membrane
During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752).
Detected on lysosomes in mature dendritic cells (PubMed:9768752).

Topology

Lumenal: 28-381
Helical: 382-402
Cytoplasmic: 403-416

Wang, Z., Wang, X., Jin, R., Liu, F., Rao, H., Wei, L., ... & Feng, B. (2023). LAMP3 expression in the liver is involved in T cell activation and adaptive immune regulation in hepatitis B virus infection. Frontiers in Immunology, 14, 1127572.

Tanaka, T., Warner, B. M., Michael, D. G., Nakamura, H., Odani, T., Yin, H., ... & Chiorini, J. A. (2022). LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization. Autophagy, 18(7), 1629-1647.

Nakamura, H., Tanaka, T., Zheng, C., Afione, S. A., Warner, B. M., Noguchi, M., ... & Chiorini, J. A. (2022). Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy. Scientific Reports, 12(1), 18570.

Sun, Q., Wang, F., Chen, Q., Sarid, R., Li, X., & Kuang, E. (2022). Upregulation of ATF4-LAMP3 Axis by ORF45 Facilitates Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus. Journal of Virology, 96(23), e01456-22.

Huang, F., Ma, G., Zhou, X., Zhu, X., Yu, X., Ding, F., ... & Liu, Z. (2020). Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma. Cancer Letters, 479, 100-111.

Tanaka, T., Warner, B. M., Odani, T., Ji, Y., Mo, Y. Q., Nakamura, H., ... & Chiorini, J. A. (2020). LAMP3 induces apoptosis and autoantigen release in Sjögren’s syndrome patients. Scientific Reports, 10(1), 15169.

Burton, T. D., Fedele, A. O., Xie, J., Sandeman, L. Y., & Proud, C. G. (2020). The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4. Journal of Biological Chemistry, 295(21), 7418-7430.

Nishimura, J., Tanaka, H., Yamakoshi, Y., Hiramatsu, S., Tamura, T., Toyokawa, T., ... & Ohira, M. (2019). Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma. Esophagus, 16, 333-344.

Yang, C., Shen, S., Zheng, X., Ye, K., Sun, Y., Lu, Y., & Ge, H. (2019). Long noncoding RNA HAGLR acts as a microRNA‐143‐5p sponge to regulate epithelial‐mesenchymal transition and metastatic potential in esophageal cancer by regulating LAMP3. The FASEB Journal, 33(9), 10490-10504.

Liao, X., Song, L., Zhang, L., Wang, H., Tong, Q., Xu, J., ... & Zheng, H. (2018). LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. Molecular and cellular endocrinology, 470, 160-167.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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