Mouse Anti-LCMT1 Recombinant Antibody (CBYCL-159) (CBMAB-L0060-YC)

Name: Mouse Anti-LCMT1 Recombinant Antibody (CBYCL-159)
SKU: CBMAB-L0060-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-159

Application

Immunogen

Recombinant mouse PPM1 (protein phosphatase methyltransferase 1)

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

leucine carboxyl methyltransferase 1

Introduction

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A.ous

Entrez Gene ID

30949

UniProt ID

A2RTH5

Alternative Names

CGI-68; LCMT; PPMT1

Function

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

Biological Process

C-terminal protein methylationManual Assertion Based On ExperimentIDA:MGI
Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
G2/M transition of mitotic cell cycleTAS:Reactome
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:MGI
Protein methylationManual Assertion Based On ExperimentIMP:MGI
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:MGI
Regulation of glucose metabolic processIEA:Ensembl
Regulation of mitotic cell cycle spindle assembly checkpointManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Cytosol
Nucleoplasm

Rasool, R. U., O’Connor, C. M., Das, C. K., Alhusayan, M., Verma, B. K., Islam, S., ... & Asangani, I. A. (2023). Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance. Nature Communications, 14(1), 5253.

Li, Y., Liang, N., Tang, T., Zheng, Z., Chen, M., Mo, J., ... & Li, X. (2023). Low-dose benzo [a] pyrene exposure induces hepatic lipid deposition through LCMT1/PP2Ac-mediated autophagy inhibition. Food and Chemical Toxicology, 113986.

Mo, J., Wang, X., Liang, N., Zhang, N., Li, Y., Zheng, Z., ... & Li, X. (2023). Hepatic leucine carboxyl methyltransferase 1 (LCMT1) contributes to high fat diet-induced glucose intolerance through regulation of glycogen metabolism. The Journal of Nutritional Biochemistry, 117, 109321.

Zhang, N., Lu, C., Mo, J., Wang, X., Liao, S., Liang, N., ... & Li, X. (2023). LCMT1 indicates poor prognosis and is essential for cell proliferation in hepatocellular carcinoma. Translational Oncology, 27, 101572.

Lei, L., Feng, J., Wu, G., Wei, Z., Wang, J. Z., Zhang, B., ... & Li, H. L. (2022). HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. International Journal of Molecular Sciences, 23(24), 16140.

Staniszewski, A., Zhang, H., Asam, K., Pitstick, R., Kavanaugh, M. P., Arancio, O., & Nicholls, R. E. (2020). Reduced expression of the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, alters sensitivity to beta-amyloid-induced cognitive and electrophysiological impairments in mice. Journal of Neuroscience, 40(23), 4596-4608.

Wang, X., Tang, S., Qin, F., Liu, Y., Liang, Z., Cai, H., ... & Li, X. (2019). Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability. Redox Report, 24(1), 1-9.

Park, H. J., Lee, K. W., Oh, S., Yan, R., Zhang, J., Beach, T. G., ... & Mouradian, M. M. (2018). Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 77(2), 139-148.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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