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Mouse Anti-LCMT1 Recombinant Antibody (CBYCL-159) (CBMAB-L0060-YC)

Provided herein is a Mouse monoclonal antibody against Mouse LCMT1. The antibody can be used for immunoassay techniques, such as WB.
See all LCMT1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBYCL-159
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant mouse PPM1 (protein phosphatase methyltransferase 1)
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine carboxyl methyltransferase 1
Introduction
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A.ous
Entrez Gene ID
30949
UniProt ID
A2RTH5
Alternative Names
CGI-68; LCMT; PPMT1
Function
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Biological Process
C-terminal protein methylationManual Assertion Based On ExperimentIDA:MGI
Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
G2/M transition of mitotic cell cycleTAS:Reactome
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:MGI
Protein methylationManual Assertion Based On ExperimentIMP:MGI
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:MGI
Regulation of glucose metabolic processIEA:Ensembl
Regulation of mitotic cell cycle spindle assembly checkpointManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Cytosol
Nucleoplasm

Rasool, R. U., O’Connor, C. M., Das, C. K., Alhusayan, M., Verma, B. K., Islam, S., ... & Asangani, I. A. (2023). Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance. Nature Communications, 14(1), 5253.

Li, Y., Liang, N., Tang, T., Zheng, Z., Chen, M., Mo, J., ... & Li, X. (2023). Low-dose benzo [a] pyrene exposure induces hepatic lipid deposition through LCMT1/PP2Ac-mediated autophagy inhibition. Food and Chemical Toxicology, 113986.

Mo, J., Wang, X., Liang, N., Zhang, N., Li, Y., Zheng, Z., ... & Li, X. (2023). Hepatic leucine carboxyl methyltransferase 1 (LCMT1) contributes to high fat diet-induced glucose intolerance through regulation of glycogen metabolism. The Journal of Nutritional Biochemistry, 117, 109321.

Zhang, N., Lu, C., Mo, J., Wang, X., Liao, S., Liang, N., ... & Li, X. (2023). LCMT1 indicates poor prognosis and is essential for cell proliferation in hepatocellular carcinoma. Translational Oncology, 27, 101572.

Lei, L., Feng, J., Wu, G., Wei, Z., Wang, J. Z., Zhang, B., ... & Li, H. L. (2022). HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. International Journal of Molecular Sciences, 23(24), 16140.

Staniszewski, A., Zhang, H., Asam, K., Pitstick, R., Kavanaugh, M. P., Arancio, O., & Nicholls, R. E. (2020). Reduced expression of the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, alters sensitivity to beta-amyloid-induced cognitive and electrophysiological impairments in mice. Journal of Neuroscience, 40(23), 4596-4608.

Wang, X., Tang, S., Qin, F., Liu, Y., Liang, Z., Cai, H., ... & Li, X. (2019). Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability. Redox Report, 24(1), 1-9.

Park, H. J., Lee, K. W., Oh, S., Yan, R., Zhang, J., Beach, T. G., ... & Mouradian, M. M. (2018). Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 77(2), 139-148.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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