Human Recombinant LCMT1, Active protein, GST Tag (V2LY-0526-LY5266)

Name: Human Recombinant LCMT1, Active protein, GST Tag
SKU: V2LY-0526-LY5266
Rating: 5 (1 reviews)

See all LCMT1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant LCMT1, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 63 kDa.

Molecule Mass

63 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Urea

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

leucine carboxyl methyltransferase 1

Function

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

Biological Process

C-terminal protein methylationManual Assertion Based On ExperimentIDA:MGI
Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
G2/M transition of mitotic cell cycleTAS:Reactome
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:MGI
Protein methylationManual Assertion Based On ExperimentIMP:MGI
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:MGI
Regulation of glucose metabolic processIEA:Ensembl
Regulation of mitotic cell cycle spindle assembly checkpointManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Cytosol
Nucleoplasm

Rasool, R. U., O’Connor, C. M., Das, C. K., Alhusayan, M., Verma, B. K., Islam, S., ... & Asangani, I. A. (2023). Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance. Nature Communications, 14(1), 5253.

Li, Y., Liang, N., Tang, T., Zheng, Z., Chen, M., Mo, J., ... & Li, X. (2023). Low-dose benzo [a] pyrene exposure induces hepatic lipid deposition through LCMT1/PP2Ac-mediated autophagy inhibition. Food and Chemical Toxicology, 113986.

Mo, J., Wang, X., Liang, N., Zhang, N., Li, Y., Zheng, Z., ... & Li, X. (2023). Hepatic leucine carboxyl methyltransferase 1 (LCMT1) contributes to high fat diet-induced glucose intolerance through regulation of glycogen metabolism. The Journal of Nutritional Biochemistry, 117, 109321.

Zhang, N., Lu, C., Mo, J., Wang, X., Liao, S., Liang, N., ... & Li, X. (2023). LCMT1 indicates poor prognosis and is essential for cell proliferation in hepatocellular carcinoma. Translational Oncology, 27, 101572.

Lei, L., Feng, J., Wu, G., Wei, Z., Wang, J. Z., Zhang, B., ... & Li, H. L. (2022). HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. International Journal of Molecular Sciences, 23(24), 16140.

Staniszewski, A., Zhang, H., Asam, K., Pitstick, R., Kavanaugh, M. P., Arancio, O., & Nicholls, R. E. (2020). Reduced expression of the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, alters sensitivity to beta-amyloid-induced cognitive and electrophysiological impairments in mice. Journal of Neuroscience, 40(23), 4596-4608.

Wang, X., Tang, S., Qin, F., Liu, Y., Liang, Z., Cai, H., ... & Li, X. (2019). Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability. Redox Report, 24(1), 1-9.

Park, H. J., Lee, K. W., Oh, S., Yan, R., Zhang, J., Beach, T. G., ... & Mouradian, M. M. (2018). Protein phosphatase 2A and its methylation modulating enzymes LCMT-1 and PME-1 are dysregulated in tauopathies of progressive supranuclear palsy and Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 77(2), 139-148.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant LCMT1, Active protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human LCMT1 ELISA Kit (CAT#: V2LY-0626-LY5708)

Related Products

Mouse Anti-LCMT1 Recombinant Antibody (CBYCL-159) (CAT#: CBMAB-L0060-YC)

Mouse Anti-LCMT1 Recombinant Antibody (1E7) (CAT#: CBMAB-L0816-YJ)

Mouse Anti-Lcmt1 Recombinant Antibody (4A4) (CAT#: CBMAB-L2873-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (CBYJL-1263) (CAT#: CBMAB-L0818-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (2C9) (CAT#: CBMAB-L0820-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (3D3) (CAT#: CBMAB-L0822-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (3F4) (CAT#: CBMAB-L0823-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (CBYJL-1264) (CAT#: CBMAB-L0819-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (5D5) (CAT#: CBMAB-L0825-YJ)

Mouse Anti-LCMT1 Recombinant Antibody (4A5) (CAT#: CBMAB-L0824-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry