LCMT1
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).
Full Name
leucine carboxyl methyltransferase 1
Function
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Biological Process
C-terminal protein methylationManual Assertion Based On ExperimentIDA:MGI
Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
G2/M transition of mitotic cell cycleTAS:Reactome
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:MGI
Protein methylationManual Assertion Based On ExperimentIMP:MGI
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:MGI
Regulation of glucose metabolic processIEA:Ensembl
Regulation of mitotic cell cycle spindle assembly checkpointManual Assertion Based On ExperimentIMP:MGI
Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
G2/M transition of mitotic cell cycleTAS:Reactome
Negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIMP:MGI
Protein methylationManual Assertion Based On ExperimentIMP:MGI
Regulation of apoptotic processManual Assertion Based On ExperimentIMP:MGI
Regulation of glucose metabolic processIEA:Ensembl
Regulation of mitotic cell cycle spindle assembly checkpointManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Cytosol
Nucleoplasm
Nucleoplasm
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Anti-LCMT1 antibodies
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CompareTarget: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F8
Application*: F, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E7
Application*: F, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYCL-159
Application*: WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCL-158
Application*: E, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: 4A4
Application*: WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D5
Application*: WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A5
Application*: F, IF, IH, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F4
Application*: F, IF, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D3
Application*: E, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2C9
Application*: WB, P
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1264
Application*: F, IF, IH, WB
Target: LCMT1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1263
Application*: LA
Target: LCMT1
Sensitivity: 0.014 ng/mL
Detection Range: 0.05-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: LCMT1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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