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Rabbit Anti-LDHA Recombinant Antibody (C28H7) (CBMAB-CP1370-LY)

The product is antibody recognizes LDHA. The antibody C28H7 immunoassay techniques such as: WB,IHC-P.
See all LDHA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
C28H7
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human LDHA.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LDHA
Entrez Gene ID
Human3939
Mouse16828
Rat24533
Monkey694309
UniProt ID
HumanP00338
MouseP06151
RatP04642
MonkeyQ9BE24
Biological Process
Glycolytic process1 PublicationNAS:UniProtKB
Lactate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Pyruvate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Substantia nigra developmentHEP:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Glycogen storage disease 11 (GSD11):
A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.
PTM
ISGylated.

Ban, E. J., Kim, D., Kim, J. K., Kang, S. W., Lee, J., Jeong, J. J., ... & Kim, K. (2021). Lactate dehydrogenase A as a potential new biomarker for thyroid cancer. Endocrinology and Metabolism, 36(1), 96-105.

Dai, C., Li, Q., May, H. I., Li, C., Zhang, G., Sharma, G., ... & Wang, Z. V. (2020). Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress. Cell reports, 32(9).

Yu, H., Yin, Y., Yi, Y., Cheng, Z., Kuang, W., Li, R., ... & Zhang, G. (2020). Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia. Cancer Communications, 40(10), 501-517.

Hong, M., Zhang, X. B., Xiang, F., Fei, X., Ouyang, X. L., & Peng, X. C. (2020). MiR-34a suppresses osteoblast differentiation through glycolysis inhibition by targeting lactate dehydrogenase-A (LDHA). In Vitro Cellular & Developmental Biology-Animal, 56, 480-487.

Woodford, M. R., Chen, V. Z., Backe, S. J., Bratslavsky, G., & Mollapour, M. (2019). Structural and functional regulation of lactate dehydrogenase-A in cancer. Future Medicinal Chemistry, 12(5), 439-455.

Jafary, F., Ganjalikhany, M. R., Moradi, A., Hemati, M., & Jafari, S. (2019). Novel peptide inhibitors for lactate dehydrogenase A (LDHA): a survey to inhibit LDHA activity via disruption of protein-protein interaction. Scientific reports, 9(1), 4686.

Feng, Y., Xiong, Y., Qiao, T., Li, X., Jia, L., & Han, Y. (2018). Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer medicine, 7(12), 6124-6136.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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