Mouse Recombinant LDHA protein, His Tag (V2LY-0526-LY8610)

Name: Mouse Recombinant LDHA protein, His Tag
SKU: V2LY-0526-LY8610
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant LDHA protein, His Tag consist of Amino Acid: 1-332 and predicts a molecular mass of 36.5 kDa.

Molecule Mass

36.5 kDa

Sequence

Amino Acid: 1-332

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LDHA

Biological Process

Glycolytic process1 PublicationNAS:UniProtKB
Lactate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Pyruvate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Substantia nigra developmentHEP:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Glycogen storage disease 11 (GSD11):
A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.

PTM

ISGylated.

Ban, E. J., Kim, D., Kim, J. K., Kang, S. W., Lee, J., Jeong, J. J., ... & Kim, K. (2021). Lactate dehydrogenase A as a potential new biomarker for thyroid cancer. Endocrinology and Metabolism, 36(1), 96-105.

Dai, C., Li, Q., May, H. I., Li, C., Zhang, G., Sharma, G., ... & Wang, Z. V. (2020). Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress. Cell reports, 32(9).

Yu, H., Yin, Y., Yi, Y., Cheng, Z., Kuang, W., Li, R., ... & Zhang, G. (2020). Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia. Cancer Communications, 40(10), 501-517.

Hong, M., Zhang, X. B., Xiang, F., Fei, X., Ouyang, X. L., & Peng, X. C. (2020). MiR-34a suppresses osteoblast differentiation through glycolysis inhibition by targeting lactate dehydrogenase-A (LDHA). In Vitro Cellular & Developmental Biology-Animal, 56, 480-487.

Woodford, M. R., Chen, V. Z., Backe, S. J., Bratslavsky, G., & Mollapour, M. (2019). Structural and functional regulation of lactate dehydrogenase-A in cancer. Future Medicinal Chemistry, 12(5), 439-455.

Jafary, F., Ganjalikhany, M. R., Moradi, A., Hemati, M., & Jafari, S. (2019). Novel peptide inhibitors for lactate dehydrogenase A (LDHA): a survey to inhibit LDHA activity via disruption of protein-protein interaction. Scientific reports, 9(1), 4686.

Feng, Y., Xiong, Y., Qiao, T., Li, X., Jia, L., & Han, Y. (2018). Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. Cancer medicine, 7(12), 6124-6136.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Recombinant LDHA protein, His Tag (CAT#: V2LY-0526-LY9508)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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