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Mouse Anti-LDHB Recombinant Antibody (2H6) (CBMAB-A4899-LY)

The product is antibody recognizes LDHB. The antibody 2H6 immunoassay techniques such as: WB, ELISA.
See all LDHB antibodies
Published Data
Fig.1 LDHB Markers for cytosol was determined by Western blotting.
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Fig.2 Immunohistochemistry on wax sections from a control eye from a patient with diabetes using antibodies against LDHB.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
LDHB (AAH02362.1, 1 a.a. ~ 334 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LDHB
Entrez Gene ID
3945
UniProt ID
P07195
Alternative Names
LDH-H; TRG-5
Biological Process
Carbohydrate metabolic processIEA:InterPro
Lactate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Pyruvate metabolic processManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Cytoplasm
Mitochondrion inner membrane
Involvement in disease
Lactate dehydrogenase B deficiency (LDHBD):
A condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected.

Wulandari, F., & Hanifa, M. (2023). Integrative bioinformatics reveals the lactate dehydrogenase B (LDHB) significance in colon adenocarcinoma. Molecular and Cellular Biomedical Sciences, 7(2), 98-108.

Guo, B., Shu, H., Luo, L., Liu, X., Ma, Y., Zhang, J., ... & Zhang, C. (2023). Lactate Conversion by Lactate Dehydrogenase B Is Involved in Beige Adipocyte Differentiation and Thermogenesis in Mice. Nutrients, 15(22), 4846.

Deng, H., Gao, Y., Trappetti, V., Hertig, D., Karatkevich, D., Losmanova, T., ... & Marti, T. M. (2022). Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. Cellular and molecular life sciences, 79(8), 445.

Wang, R., Li, J., Zhang, C., Guan, X., Qin, B., Jin, R., ... & Cheng, L. (2022). Lactate dehydrogenase B is required for pancreatic cancer cell immortalization through activation of telomerase activity. Frontiers in Oncology, 12, 821620.

Shibata, S., Sogabe, S., Miwa, M., Fujimoto, T., Takakura, N., Naotsuka, A., ... & Soga, T. (2021). Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Scientific reports, 11(1), 21353.

Wang, T., Chen, K., Yao, W., Zheng, R., He, Q., Xia, J., ... & Huang, F. (2021). Acetylation of lactate dehydrogenase B drives NAFLD progression by impairing lactate clearance. Journal of Hepatology, 74(5), 1038-1052.

Frank, A. C., Raue, R., Fuhrmann, D. C., Sirait-Fischer, E., Reuse, C., Weigert, A., ... & Brüne, B. (2021). Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment. Theranostics, 11(15), 7570.

Papaneophytou, C., Zervou, M. E., & Theofanous, A. (2021). Optimization of a colorimetric assay to determine lactate dehydrogenase B activity using design of experiments. SLAS DISCOVERY: Advancing the Science of Drug Discovery, 26(3), 383-399.

Hong, S. M., Lee, Y. K., Park, I., Kwon, S. M., Min, S., & Yoon, G. (2019). Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)–PDH kinase axis. Journal of Biological Chemistry, 294(19), 7810-7820.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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