Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-224) (CBMAB-L0125-YC)

Name: Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-224)
SKU: CBMAB-L0125-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-224

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LEFTY1

Introduction

LEFTY1 is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development.

Entrez Gene ID

10637

UniProt ID

O75610

Alternative Names

LEFTB; LEFTYB

Function

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

Biological Process

BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Determination of left/right symmetryISS:BHF-UCL
Heart morphogenesisISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted

PTM

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Ashiq, S., & Sabar, M. F. (2023). Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. Molecular Biology Reports, 1-8.

Zhao, Y., Yu, Y., Wang, S., Li, J., & Teng, L. (2022). Small extracellular vesicles encapsulating lefty1 mRNA inhibit hepatic fibrosis. Asian Journal of Pharmaceutical Sciences, 17(5), 630-640.

Li, C. Y., Zhang, J. R., Li, X. X., Zhao, L., Xi, H., Hu, W. N., & Li, S. N. (2021). Lefty1 ameliorates post-infarction fibrosis by suppressing p-Smad2 and p-ERK1/2 signaling pathways. Journal of cardiovascular translational research, 14, 636-646.

Skok, D. J., Hauptman, N., Jerala, M., & Zidar, N. (2021). Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease. Genes, 12(10), 1477.

Zabala, M., Lobo, N. A., Antony, J., Heitink, L. S., Gulati, G. S., Lam, J., ... & Clarke, M. F. (2020). LEFTY1 is a dual-SMAD inhibitor that promotes mammary progenitor growth and tumorigenesis. Cell Stem Cell, 27(2), 284-299.

Zhang, L., Liu, X., Liang, J., Wu, J., Tan, D., & Hu, W. (2020). Lefty-1 inhibits renal epithelial–mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Journal of Molecular Histology, 51(1), 77-87.

Zhang, L., Xu, C., Hu, W., Wu, P., Qin, C., & Zhang, J. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway. International journal of molecular medicine, 41(3), 1293-1304.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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