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Rabbit Anti-LEFTY1 Recombinant Antibody (D7E3G) (CBMAB-CP1376-LY)

The product is antibody recognizes LEFTY1. The antibody D7E3G immunoassay techniques such as: WB.
See all LEFTY1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D7E3G
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro108 of human lefty1 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LEFTY1
Entrez Gene ID
Human10637
Mouse13590
Rat498299
Monkey699924
UniProt ID
HumanO75610
MouseQ64280
RatD4A670
Function
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Determination of left/right symmetryISS:BHF-UCL
Heart morphogenesisISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Ashiq, S., & Sabar, M. F. (2023). Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population. Molecular Biology Reports, 1-8.

Zhao, Y., Yu, Y., Wang, S., Li, J., & Teng, L. (2022). Small extracellular vesicles encapsulating lefty1 mRNA inhibit hepatic fibrosis. Asian Journal of Pharmaceutical Sciences, 17(5), 630-640.

Li, C. Y., Zhang, J. R., Li, X. X., Zhao, L., Xi, H., Hu, W. N., & Li, S. N. (2021). Lefty1 ameliorates post-infarction fibrosis by suppressing p-Smad2 and p-ERK1/2 signaling pathways. Journal of cardiovascular translational research, 14, 636-646.

Skok, D. J., Hauptman, N., Jerala, M., & Zidar, N. (2021). Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease. Genes, 12(10), 1477.

Zabala, M., Lobo, N. A., Antony, J., Heitink, L. S., Gulati, G. S., Lam, J., ... & Clarke, M. F. (2020). LEFTY1 is a dual-SMAD inhibitor that promotes mammary progenitor growth and tumorigenesis. Cell Stem Cell, 27(2), 284-299.

Zhang, L., Liu, X., Liang, J., Wu, J., Tan, D., & Hu, W. (2020). Lefty-1 inhibits renal epithelial–mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Journal of Molecular Histology, 51(1), 77-87.

Zhang, L., Xu, C., Hu, W., Wu, P., Qin, C., & Zhang, J. (2018). Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway. International journal of molecular medicine, 41(3), 1293-1304.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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