LEFTY1

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq]
Full Name
LEFTY1
Function
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Determination of left/right symmetryISS:BHF-UCL
Heart morphogenesisISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
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Anti-LEFTY1 antibodies

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Mouse Anti-LEFTY1 Recombinant Antibody (A887) (CBMAB-AP4250LY)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A887
Application*: ICC, IHC, IP, WB
Datasheet SDS

Rabbit Anti-LEFTY1 Recombinant Antibody (D7E3G) (CBMAB-CP1376-LY)

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Target: LEFTY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D7E3G
Application*: WB
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (1F9) (CBMAB-A4914-LY)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F9
Application*: E, E
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (2E10) (CBMAB-A4913-LY)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E10
Application*: IP, E
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-226) (CBMAB-L0127-YC)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-226
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-225) (CBMAB-L0126-YC)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-225
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-224) (CBMAB-L0125-YC)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCL-224
Application*: E, WB
Datasheet SDS

Rat Anti-Lefty1 Recombinant Antibody (CBYJL-2582) (CBMAB-L3017-YJ)

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Target: Lefty1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJL-2582
Application*: WB
Datasheet SDS

Rabbit Anti-LEFTY1 Recombinant Antibody (CBYJL-1415) (CBMAB-L1080-YJ)

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Target: LEFTY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-1415
Application*: WB, IP
Datasheet SDS

Rabbit Anti-LEFTY1 Recombinant Antibody (CBYJL-1414) (CBMAB-L1079-YJ)

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Target: LEFTY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJL-1414
Application*: WB
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (4D7) (CBMAB-L1078-YJ)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D7
Application*: E, IP
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (CBYJL-1413) (CBMAB-L1075-YJ)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1413
Application*: E, WB
Datasheet SDS

Mouse Anti-LEFTY1 Recombinant Antibody (CBYJL-1412) (CBMAB-L1073-YJ)

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Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1412
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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