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LEFTY1

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq]
Full Name
LEFTY1
Function
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Biological Process
BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Determination of left/right symmetryISS:BHF-UCL
Heart morphogenesisISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
PTM
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Anti-LEFTY1 antibodies

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Mouse Anti-LEFTY1 Recombinant Antibody (2E10) (CBMAB-A4913-LY)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E10
Application*: IP, E

Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-224) (CBMAB-L0125-YC)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCL-224
Application*: E, WB

Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-225) (CBMAB-L0126-YC)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-225
Application*: WB, IC, P, C, E

Mouse Anti-LEFTY1 Recombinant Antibody (CBYCL-226) (CBMAB-L0127-YC)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-226
Application*: WB, IC, P, C, E

Mouse Anti-LEFTY1 Recombinant Antibody (1F9) (CBMAB-A4914-LY)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F9
Application*: E, E

Rabbit Anti-LEFTY1 Recombinant Antibody (D7E3G) (CBMAB-CP1376-LY)

Datasheet SDS
Target: LEFTY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D7E3G
Application*: WB

Mouse Anti-LEFTY1 Recombinant Antibody (CBYJL-1412) (CBMAB-L1073-YJ)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1412
Application*: E

Mouse Anti-LEFTY1 Recombinant Antibody (CBYJL-1413) (CBMAB-L1075-YJ)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1413
Application*: E, WB

Mouse Anti-LEFTY1 Recombinant Antibody (4D7) (CBMAB-L1078-YJ)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D7
Application*: E, IP

Rabbit Anti-LEFTY1 Recombinant Antibody (CBYJL-1414) (CBMAB-L1079-YJ)

Datasheet SDS
Target: LEFTY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJL-1414
Application*: WB

Rabbit Anti-LEFTY1 Recombinant Antibody (CBYJL-1415) (CBMAB-L1080-YJ)

Datasheet SDS
Target: LEFTY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-1415
Application*: WB, IP

Rat Anti-Lefty1 Recombinant Antibody (CBYJL-2582) (CBMAB-L3017-YJ)

Datasheet SDS
Target: Lefty1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJL-2582
Application*: WB

Mouse Anti-LEFTY1 Recombinant Antibody (A887) (CBMAB-AP4250LY)

Datasheet SDS
Target: LEFTY1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A887
Application*: ICC, IHC, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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