Rat Anti-LGALS2 Recombinant Antibody (747307) (CBMAB-G1108-LY)

Name: Rat Anti-LGALS2 Recombinant Antibody (747307)
SKU: CBMAB-G1108-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

747307

Application

Immunogen

E. coli-derived recombinant mouse Galectin-2, Ser2-Glu130, Accession # Q9CQW5

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

lyophilized

Buffer

Trehalose

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Galectin 2

Introduction

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.

Entrez Gene ID

107753

UniProt ID

Q9CQW5

Alternative Names

2200008F12Rik; AI324147

Function

This protein binds beta-galactoside. Its physiological function is not yet known.

Biological Process

Cell-cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of inflammatory responseIEA:Ensembl
T cell homeostasisManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Cytoplasm
Galectin complex

He, S., Ji, Z., Zhang, Q., Zhang, X., Chen, J., Hu, J., ... & Ding, Y. (2023). Investigation of LGALS2 expression in the TCGA database reveals its clinical relevance in breast cancer immunotherapy and drug resistance. Scientific Reports, 13(1), 17445.

Jiang, H., Sun, Q., Huang, Z., Chen, H., Chen, L., & He, X. (2023). LGALS2 and EGR1: markers of endometriosis for predictive, preventive and personalized medicine.

Ji, P., Gong, Y., Jin, M. L., Wu, H. L., Guo, L. W., Pei, Y. C., ... & Shao, Z. M. (2022). In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer. Science Advances, 8(26), eabl8247.

Chetry, M., Bhandari, A., Feng, R., Song, X., Wang, P., & Lin, J. (2022). Overexpression of galectin2 (LGALS2) predicts a better prognosis in human breast cancer. American Journal of Translational Research, 14(4), 2301.

Xu, D., Guo, L., Zhang, S., & Hou, Q. (2022). LGALS2 suppresses the progression of papillary thyroid carcinoma by regulating the PI3K/AKT pathway. Gland Surgery, 11(9), 1518.

Xu, W. D., Wu, Q., He, Y. W., Huang, A. F., Lan, Y. Y., Fu, L., ... & Liu, X. Y. (2021). Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis. Cellular Immunology, 368, 104419.

Li, H., Zhao, L., Lau, Y. S., Zhang, C., & Han, R. (2021). Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth. Oncogene, 40(1), 177-188.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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