Sign in or Register   Sign in or Register
  |  

Mouse Anti-LGI1 Recombinant Antibody (A897) (CBMAB-AP11472LY)

The product is antibody recognizes LGI1. The antibody A897 immunoassay techniques such as: ICC/IF, IHC, WB.
See all LGI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A897
Antibody Isotype
IgG2a
Application
ICC/IF, IHC, WB

Basic Information

Immunogen
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LGI1
Entrez Gene ID
Human9211
Mouse56839
Rat252892
UniProt ID
HumanO95970
MouseQ9JIA1
RatQ8K4Y5
Alternative Names
ADLTE Antibody, ADPAEF Antibody, ADPEAF Antibody, Epitempin 1 Antibody, EPT Antibody, ETL1 Antibody, IB1099 Antibody, leucine rich glioma inactivated 1 Antibody, OTTHUMP00000020121 Antibody, OTTHUMP00000020122
Antibody
Function
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity).
Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
Biological Process
Axon guidanceManual Assertion Based On ExperimentIMP:DFLAT
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection developmentManual Assertion Based On ExperimentIMP:DFLAT
Neurotransmitter receptor localization to postsynaptic specialization membraneIEA:Ensembl
Positive regulation of cell growthManual Assertion Based On ExperimentIMP:DFLAT
Positive regulation of synaptic transmissionISS:UniProtKB
Cellular Location
Secreted
Cell junction, synapse
Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.
Involvement in disease
Epilepsy, familial temporal lobe, 1 (ETL1):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
PTM
Glycosylated.

Teng, Y., Li, T., Yang, Z., Su, M., Ni, J., Wei, M., ... & Tian, J. (2022). Clinical features and therapeutic effects of anti-leucine-rich glioma inactivated 1 encephalitis: a systematic review. Frontiers in Neurology, 12, 791014.

Huang, X., Fan, C., Gao, L., Li, L., Ye, J., & Shen, H. (2022). Clinical features, immunotherapy, and outcomes of anti-leucine-rich glioma-inactivated-1 encephalitis. The Journal of Neuropsychiatry and Clinical Neurosciences, 34(2), 141-148.

Qiao, S., Wu, H. K., Liu, L. L., Wang, M. L., Zhang, R. R., Han, T., & Liu, X. W. (2021). Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis: a multi-center study. Neuropsychiatric Disease and Treatment, 203-212.

Li, Y., Song, F., Liu, W., & Wang, Y. (2021). Clinical features of nine cases of leucine-rich glioma inactivated 1 protein antibody-associated encephalitis. Acta Neurologica Belgica, 121, 889-897.

Lin, N., Liu, Q., Chen, J., Jin, L., Huang, Y., Lu, Q., & Guan, H. (2021). Long-term seizure outcomes in patients with anti-Leucine-rich glioma-inactivated 1 encephalitis. Epilepsy & Behavior, 122, 108159.

Zhao, Q., Sun, L., Zhao, D., Chen, Y., Li, M., Lu, Y., ... & Lin, W. (2021). Clinical features of anti-leucine-rich glioma-inactivated 1 encephalitis in northeast China. Clinical Neurology and Neurosurgery, 203, 106542.

Roberto, K. T., Espiritu, A. I., Fernandez, M. L. L., & Gutierrez, J. C. (2020). Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review. Epilepsy & Behavior, 112, 107462.

Jia-qian, T. A. N. G., Li, X. U., Zhi-yao, Y. U., HUANG, L., & Fang, L. I. U. (2019). Clinical analysis of patients with anti-leucine-rich glioma-inactivated 1 antibody-associated limbic encephalitis. Chinese Journal of Contemporary Neurology & Neurosurgery, 19(4), 271.

Yang, X., Li, A. N., Zhao, X. H., Liu, X. W., & Wang, S. J. (2019). Clinical features of patients with anti-leucine-rich glioma inactivated-1 protein associated encephalitis: a Chinese case series. International Journal of Neuroscience, 129(8), 754-761.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LGI1 Recombinant Antibody (A897)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare