Mouse Anti-LGI1 Recombinant Antibody (A897) (CBMAB-AP11472LY)

Name: Mouse Anti-LGI1 Recombinant Antibody (A897)
SKU: CBMAB-AP11472LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A897

Application

ICC/IF, IHC, WB

Immunogen

Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LGI1

Entrez Gene ID

Human	9211
Mouse	56839
Rat	252892

UniProt ID

Human	O95970
Mouse	Q9JIA1
Rat	Q8K4Y5

Alternative Names

ADLTE Antibody, ADPAEF Antibody, ADPEAF Antibody, Epitempin 1 Antibody, EPT Antibody, ETL1 Antibody, IB1099 Antibody, leucine rich glioma inactivated 1 Antibody, OTTHUMP00000020121 Antibody, OTTHUMP00000020122
Antibody

Function

SMC-461D

Biological Process

Axon guidanceManual Assertion Based On ExperimentIMP:DFLAT
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection developmentManual Assertion Based On ExperimentIMP:DFLAT
Neurotransmitter receptor localization to postsynaptic specialization membraneIEA:Ensembl
Positive regulation of cell growthManual Assertion Based On ExperimentIMP:DFLAT
Positive regulation of synaptic transmissionISS:UniProtKB

Cellular Location

Secreted
Cell junction, synapse
Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.

Involvement in disease

Epilepsy, familial temporal lobe, 1 (ETL1):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.

PTM

Glycosylated.

Teng, Y., Li, T., Yang, Z., Su, M., Ni, J., Wei, M., ... & Tian, J. (2022). Clinical features and therapeutic effects of anti-leucine-rich glioma inactivated 1 encephalitis: a systematic review. Frontiers in Neurology, 12, 791014.

Huang, X., Fan, C., Gao, L., Li, L., Ye, J., & Shen, H. (2022). Clinical features, immunotherapy, and outcomes of anti-leucine-rich glioma-inactivated-1 encephalitis. The Journal of Neuropsychiatry and Clinical Neurosciences, 34(2), 141-148.

Qiao, S., Wu, H. K., Liu, L. L., Wang, M. L., Zhang, R. R., Han, T., & Liu, X. W. (2021). Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis: a multi-center study. Neuropsychiatric Disease and Treatment, 203-212.

Li, Y., Song, F., Liu, W., & Wang, Y. (2021). Clinical features of nine cases of leucine-rich glioma inactivated 1 protein antibody-associated encephalitis. Acta Neurologica Belgica, 121, 889-897.

Lin, N., Liu, Q., Chen, J., Jin, L., Huang, Y., Lu, Q., & Guan, H. (2021). Long-term seizure outcomes in patients with anti-Leucine-rich glioma-inactivated 1 encephalitis. Epilepsy & Behavior, 122, 108159.

Zhao, Q., Sun, L., Zhao, D., Chen, Y., Li, M., Lu, Y., ... & Lin, W. (2021). Clinical features of anti-leucine-rich glioma-inactivated 1 encephalitis in northeast China. Clinical Neurology and Neurosurgery, 203, 106542.

Roberto, K. T., Espiritu, A. I., Fernandez, M. L. L., & Gutierrez, J. C. (2020). Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review. Epilepsy & Behavior, 112, 107462.

Jia-qian, T. A. N. G., Li, X. U., Zhi-yao, Y. U., HUANG, L., & Fang, L. I. U. (2019). Clinical analysis of patients with anti-leucine-rich glioma-inactivated 1 antibody-associated limbic encephalitis. Chinese Journal of Contemporary Neurology & Neurosurgery, 19(4), 271.

Yang, X., Li, A. N., Zhao, X. H., Liu, X. W., & Wang, S. J. (2019). Clinical features of patients with anti-leucine-rich glioma inactivated-1 protein associated encephalitis: a Chinese case series. International Journal of Neuroscience, 129(8), 754-761.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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