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Rabbit Anti-LGI1 Recombinant Antibody (BA0369) (CBMAB-0443CQ)

This product is a rabbit antibody that recognizes LGI1. The antibody BA0369 can be used for immunoassay techniques such as: IHC-P, IP, WB.
See all LGI1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0369
Antibody Isotype
IgG
Application
IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide from residues in Human Lgi1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LGI1
Introduction
The LGI1 gene encodes a secreted leucine-rich protein that is expressed in brain and plays a role in regulating postnatal glutamatergic synapse development. This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. Nobile et al. (2009) noted that the LGI1 gene contains 8 exons spanning 39.6 kb. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human9211
Mouse56839
Rat252892
UniProt ID
HumanO95970
MouseQ9JIA1
RatQ8K4Y5
Alternative Names
EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN
Function
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity).
Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
Biological Process
Axon guidanceManual Assertion Based On ExperimentIMP:DFLAT
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection developmentManual Assertion Based On ExperimentIMP:DFLAT
Neurotransmitter receptor localization to postsynaptic specialization membraneIEA:Ensembl
Positive regulation of cell growthManual Assertion Based On ExperimentIMP:DFLAT
Positive regulation of synaptic transmissionISS:UniProtKB
Cellular Location
Secreted
Cell junction, synapse
Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.
Involvement in disease
Epilepsy, familial temporal lobe, 1 (ETL1):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
PTM
Glycosylated.

Teng, Y., Li, T., Yang, Z., Su, M., Ni, J., Wei, M., ... & Tian, J. (2022). Clinical features and therapeutic effects of anti-leucine-rich glioma inactivated 1 encephalitis: a systematic review. Frontiers in Neurology, 12, 791014.

Huang, X., Fan, C., Gao, L., Li, L., Ye, J., & Shen, H. (2022). Clinical features, immunotherapy, and outcomes of anti-leucine-rich glioma-inactivated-1 encephalitis. The Journal of Neuropsychiatry and Clinical Neurosciences, 34(2), 141-148.

Qiao, S., Wu, H. K., Liu, L. L., Wang, M. L., Zhang, R. R., Han, T., & Liu, X. W. (2021). Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis: a multi-center study. Neuropsychiatric Disease and Treatment, 203-212.

Li, Y., Song, F., Liu, W., & Wang, Y. (2021). Clinical features of nine cases of leucine-rich glioma inactivated 1 protein antibody-associated encephalitis. Acta Neurologica Belgica, 121, 889-897.

Lin, N., Liu, Q., Chen, J., Jin, L., Huang, Y., Lu, Q., & Guan, H. (2021). Long-term seizure outcomes in patients with anti-Leucine-rich glioma-inactivated 1 encephalitis. Epilepsy & Behavior, 122, 108159.

Zhao, Q., Sun, L., Zhao, D., Chen, Y., Li, M., Lu, Y., ... & Lin, W. (2021). Clinical features of anti-leucine-rich glioma-inactivated 1 encephalitis in northeast China. Clinical Neurology and Neurosurgery, 203, 106542.

Roberto, K. T., Espiritu, A. I., Fernandez, M. L. L., & Gutierrez, J. C. (2020). Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review. Epilepsy & Behavior, 112, 107462.

Jia-qian, T. A. N. G., Li, X. U., Zhi-yao, Y. U., HUANG, L., & Fang, L. I. U. (2019). Clinical analysis of patients with anti-leucine-rich glioma-inactivated 1 antibody-associated limbic encephalitis. Chinese Journal of Contemporary Neurology & Neurosurgery, 19(4), 271.

Yang, X., Li, A. N., Zhao, X. H., Liu, X. W., & Wang, S. J. (2019). Clinical features of patients with anti-leucine-rich glioma inactivated-1 protein associated encephalitis: a Chinese case series. International Journal of Neuroscience, 129(8), 754-761.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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