Human LGI1 ELISA Kit (V2LY-0626-LY4799)

Name: Human LGI1 ELISA Kit
SKU: V2LY-0626-LY4799
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.021 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

63.8 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

LGI1

Function

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity).
Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.

Biological Process

Axon guidanceManual Assertion Based On ExperimentIMP:DFLAT
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron projection developmentManual Assertion Based On ExperimentIMP:DFLAT
Neurotransmitter receptor localization to postsynaptic specialization membraneIEA:Ensembl
Positive regulation of cell growthManual Assertion Based On ExperimentIMP:DFLAT
Positive regulation of synaptic transmissionISS:UniProtKB

Cellular Location

Secreted
Cell junction, synapse
Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.

Involvement in disease

Epilepsy, familial temporal lobe, 1 (ETL1):
A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.

PTM

Glycosylated.

Teng, Y., Li, T., Yang, Z., Su, M., Ni, J., Wei, M., ... & Tian, J. (2022). Clinical features and therapeutic effects of anti-leucine-rich glioma inactivated 1 encephalitis: a systematic review. Frontiers in Neurology, 12, 791014.

Huang, X., Fan, C., Gao, L., Li, L., Ye, J., & Shen, H. (2022). Clinical features, immunotherapy, and outcomes of anti-leucine-rich glioma-inactivated-1 encephalitis. The Journal of Neuropsychiatry and Clinical Neurosciences, 34(2), 141-148.

Qiao, S., Wu, H. K., Liu, L. L., Wang, M. L., Zhang, R. R., Han, T., & Liu, X. W. (2021). Clinical features and long-term outcomes of anti-leucine-rich glioma-inactivated 1 encephalitis: a multi-center study. Neuropsychiatric Disease and Treatment, 203-212.

Li, Y., Song, F., Liu, W., & Wang, Y. (2021). Clinical features of nine cases of leucine-rich glioma inactivated 1 protein antibody-associated encephalitis. Acta Neurologica Belgica, 121, 889-897.

Lin, N., Liu, Q., Chen, J., Jin, L., Huang, Y., Lu, Q., & Guan, H. (2021). Long-term seizure outcomes in patients with anti-Leucine-rich glioma-inactivated 1 encephalitis. Epilepsy & Behavior, 122, 108159.

Zhao, Q., Sun, L., Zhao, D., Chen, Y., Li, M., Lu, Y., ... & Lin, W. (2021). Clinical features of anti-leucine-rich glioma-inactivated 1 encephalitis in northeast China. Clinical Neurology and Neurosurgery, 203, 106542.

Roberto, K. T., Espiritu, A. I., Fernandez, M. L. L., & Gutierrez, J. C. (2020). Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review. Epilepsy & Behavior, 112, 107462.

Jia-qian, T. A. N. G., Li, X. U., Zhi-yao, Y. U., HUANG, L., & Fang, L. I. U. (2019). Clinical analysis of patients with anti-leucine-rich glioma-inactivated 1 antibody-associated limbic encephalitis. Chinese Journal of Contemporary Neurology & Neurosurgery, 19(4), 271.

Yang, X., Li, A. N., Zhao, X. H., Liu, X. W., & Wang, S. J. (2019). Clinical features of patients with anti-leucine-rich glioma inactivated-1 protein associated encephalitis: a Chinese case series. International Journal of Neuroscience, 129(8), 754-761.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-LGI1 Recombinant Antibody (BA0369) (CAT#: CBMAB-0443CQ)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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