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Mouse Anti-LGR5 Recombinant Antibody (A898) (CBMAB-AP11479LY)

The product is antibody recognizes LGR5. The antibody A898 immunoassay techniques such as: WB.
See all LGR5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A898
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant LGR5 protein, corresponding to amino acids 23-317 of Human LGR5
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LGR5
Entrez Gene ID
Human8549
Mouse14160
Rat299802
UniProt ID
HumanO75473
MouseQ9Z1P4
RatD4AC13
Alternative Names
Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38
Function
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Biological Process
Activation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Epithelial cell proliferation involved in renal tubule morphogenesisIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Hair follicle developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inner ear developmentIEA:Ensembl
Oocyte differentiationIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Cellular Location
Cell membrane
Golgi apparatus, trans-Golgi network membrane
Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
Topology
Extracellular: 22-561
Helical: 562-582
Cytoplasmic: 583-593
Helical: 594-614
Extracellular: 615-638
Helical: 639-659
Cytoplasmic: 660-682
Helical: 683-703
Extracellular: 704-722
Helical: 723-743
Cytoplasmic: 744-767
Helical: 768-788
Extracellular: 789-802
Helical: 803-823
Cytoplasmic: 824-907
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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