LGR5
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
Full Name
LGR5
Function
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Biological Process
Activation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Epithelial cell proliferation involved in renal tubule morphogenesisIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Hair follicle developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inner ear developmentIEA:Ensembl
Oocyte differentiationIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Epithelial cell proliferation involved in renal tubule morphogenesisIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Hair follicle developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inner ear developmentIEA:Ensembl
Oocyte differentiationIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl
Cellular Location
Cell membrane
Golgi apparatus, trans-Golgi network membrane
Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
Golgi apparatus, trans-Golgi network membrane
Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
Topology
Extracellular: 22-561
Helical: 562-582
Cytoplasmic: 583-593
Helical: 594-614
Extracellular: 615-638
Helical: 639-659
Cytoplasmic: 660-682
Helical: 683-703
Extracellular: 704-722
Helical: 723-743
Cytoplasmic: 744-767
Helical: 768-788
Extracellular: 789-802
Helical: 803-823
Cytoplasmic: 824-907
Helical: 562-582
Cytoplasmic: 583-593
Helical: 594-614
Extracellular: 615-638
Helical: 639-659
Cytoplasmic: 660-682
Helical: 683-703
Extracellular: 704-722
Helical: 723-743
Cytoplasmic: 744-767
Helical: 768-788
Extracellular: 789-802
Helical: 803-823
Cytoplasmic: 824-907
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Anti-LGR5 antibodies
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CompareTarget: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C8
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H7
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A899
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A898
Application*: WB
Target: LGR5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBAb153
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3604
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3603
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2380
Application*: WB
Target: LGR5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-2379
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2H7
Application*: IF, P, WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCL-283
Application*: WB, IP, F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-281
Application*: WB
Target: Lgr5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJL-2568
Application*: FC
Target: Lgr5
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJL-2567
Application*: FC, IC
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1565
Application*: WB, IH, IF, F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJL-1564
Application*: WB, IH, F
Target: LGR5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1563
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1562
Application*: F
Target: LGR5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-1559
Application*: F, IC, IF, IP, WB
Target: LGR5
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1558
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8C9
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJL-1557
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1556
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1555
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJL-1553
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E11
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1552
Application*: WB, IH
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1551
Application*: E, WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2B5B9
Application*: E, WB, F
Target: LGR5
Host: Rat
Antibody Isotype: IgG2b, λ
Specificity: Human, Mouse
Clone: CBYJL-1550
Application*: WB, BI, F, IF
Target: LGR5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1549
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1548
Application*: WB
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4362
Application*: F
Target: LGR5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2203
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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