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LGR5

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.

Full Name

LGR5

Function

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Biological Process

Activation of adenylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Epithelial cell proliferation involved in renal tubule morphogenesisIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Hair follicle developmentIEA:Ensembl
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inner ear developmentIEA:Ensembl
Oocyte differentiationIEA:Ensembl
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationIEA:Ensembl

Cellular Location

Cell membrane
Golgi apparatus, trans-Golgi network membrane
Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).

Topology

Extracellular: 22-561
Helical: 562-582
Cytoplasmic: 583-593
Helical: 594-614
Extracellular: 615-638
Helical: 639-659
Cytoplasmic: 660-682
Helical: 683-703
Extracellular: 704-722
Helical: 723-743
Cytoplasmic: 744-767
Helical: 768-788
Extracellular: 789-802
Helical: 803-823
Cytoplasmic: 824-907

Anti-LGR5 antibodies

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1565) (CBMAB-L1365-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1565

Application*: WB, IH, IF, F

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1564) (CBMAB-L1364-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBYJL-1564

Application*: WB, IH, F

Rabbit Anti-LGR5 Recombinant Antibody (CBYJL-1563) (CBMAB-L1363-YJ)

SDS

Target: LGR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1563

Application*: F

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1562) (CBMAB-L1362-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-1562

Application*: F

Rabbit Anti-LGR5 Recombinant Antibody (CBYJL-1559) (CBMAB-L1359-YJ)

SDS

Target: LGR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYJL-1559

Application*: F, IC, IF, IP, WB

Rat Anti-Lgr5 Recombinant Antibody (CBYJL-2568) (CBMAB-L2998-YJ)

SDS

Target: Lgr5

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYJL-2568

Application*: FC

Rat Anti-Lgr5 Recombinant Antibody (CBYJL-2567) (CBMAB-L2997-YJ)

SDS

Target: Lgr5

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJL-2567

Application*: FC, IC

Mouse Anti-LGR5 Recombinant Antibody (CBYCL-281) (CBMAB-L0182-YC)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-281

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (CBYCL-283) (CBMAB-L0184-YC)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYCL-283

Application*: WB, IP, F

Mouse Anti-LGR5 Recombinant Antibody (1C8) (CBMAB-G6350-LY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C8

Application*: F

Mouse Anti-LGR5 Recombinant Antibody (2H7) (CBMAB-G6351-LY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2H7

Application*: IF, P, WB

Rabbit Anti-LGR5 Recombinant Antibody (CBLG1-2379) (CBMAB-G6356-LY)

SDS

Target: LGR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBLG1-2379

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (CBLG1-2380) (CBMAB-G6357-LY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2380

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1548) (CBMAB-L1339-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1548

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1549) (CBMAB-L1341-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1549

Application*: F

Rat Anti-LGR5 Recombinant Antibody (CBYJL-1550) (CBMAB-L1342-YJ)

SDS

Target: LGR5

Host: Rat

Antibody Isotype: IgG2b, λ

Specificity: Human, Mouse

Clone: CBYJL-1550

Application*: WB, BI, F, IF

Mouse Anti-LGR5 Recombinant Antibody (2B5B9) (CBMAB-L1343-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2B5B9

Application*: E, WB, F

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1551) (CBMAB-L1344-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1551

Application*: E, WB

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1552) (CBMAB-L1345-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1552

Application*: WB, IH

Mouse Anti-LGR5 Recombinant Antibody (3E11) (CBMAB-L1347-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3E11

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1553) (CBMAB-L1348-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBYJL-1553

Application*: F

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1555) (CBMAB-L1351-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1555

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1556) (CBMAB-L1352-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1556

Application*: F

Mouse Anti-LGR5 Recombinant Antibody (CBYJL-1557) (CBMAB-L1353-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBYJL-1557

Application*: F

Mouse Anti-LGR5 Recombinant Antibody (7H7) (CBMAB-L1354-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7H7

Application*: F

Mouse Anti-LGR5 Recombinant Antibody (8C9) (CBMAB-L1355-YJ)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8C9

Application*: WB

Rat Anti-LGR5 Recombinant Antibody (CBYJL-1558) (CBMAB-L1358-YJ)

SDS

Target: LGR5

Host: Rat

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1558

Application*: F

Recombinant Rabbit Anti-LGR5 Antibody (CBAb153) (CBMAB-Ab153-LY)

SDS

Target: LGR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: CBAb153

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (A898) (CBMAB-AP11479LY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A898

Application*: WB

Mouse Anti-LGR5 Recombinant Antibody (A899) (CBMAB-AP11480LY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: A899

Application*: WB

Mouse Anti-LGR5 (AA 689-719) Recombinant Antibody (CBFYH-3603) (CBMAB-H4159-FY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-3603

Application*: WB

Mouse Anti-LGR5 (AA 250-550) Recombinant Antibody (CBFYH-3604) (CBMAB-H4160-FY)

SDS

Target: LGR5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-3604

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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