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Mouse Anti-LHX1 Recombinant Antibody (4F2) (CBMAB-0223-CN)

This product is a mouse antibody that recognizes LHX1 of rat. The antibody 4F2 can be used for immunoassay techniques such as: IF, IHC, WB.
See all LHX1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Chicken, Human, Mouse, Zebrafish
Clone
4F2
Antibody Isotype
IgG1
Application
IF, IHC, WB

Basic Information

Immunogen
Recombinant rat Lim2/LhxV5 (aa. 1-360).
Specificity
Rat, Chicken, Human, Mouse, Zebrafish
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LHX1
Introduction
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. The protein may play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
Entrez Gene ID
Human3975
Mouse16869
Rat257634
Chicken396381
Zebrafish30463
UniProt ID
HumanP48742
MouseP63006
RatP63007
ChickenP53411
ZebrafishQ90476
Alternative Names
Lhx1
Function
Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
Biological Process
Anatomical structure formation involved in morphogenesisISS:UniProtKB
Anatomical structure morphogenesisISS:UniProtKB
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Anterior/posterior axis specificationISS:UniProtKB
Anterior/posterior pattern specificationISS:UniProtKB
Branching involved in ureteric bud morphogenesisIEA:Ensembl
Cell-cell signalingISS:UniProtKB
Cellular response to fibroblast growth factor stimulusIEA:Ensembl
Cerebellar Purkinje cell differentiationISS:UniProtKB
Cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferationISS:UniProtKB
Cerebellum developmentISS:UniProtKB
Cervix developmentISS:UniProtKB
Comma-shaped body morphogenesisISS:UniProtKB
Dorsal spinal cord interneuron posterior axon guidanceISS:UniProtKB
Dorsal/ventral pattern formationISS:UniProtKB
Ectoderm formationISS:UniProtKB
Embryonic pattern specificationISS:UniProtKB
Embryonic retina morphogenesis in camera-type eyeISS:UniProtKB
Embryonic viscerocranium morphogenesisISS:UniProtKB
Endoderm formationISS:UniProtKB
Epithelium developmentISS:UniProtKB
Forebrain regionalizationISS:UniProtKB
Gastrulation with mouth forming secondISS:UniProtKB
Head developmentISS:UniProtKB
Horizontal cell localizationIEA:Ensembl
Kidney developmentISS:UniProtKB
Lateral motor column neuron migrationISS:UniProtKB
Mesendoderm developmentIEA:Ensembl
Mesonephric duct developmentIEA:Ensembl
Metanephric comma-shaped body morphogenesisIEA:Ensembl
Metanephric glomerulus developmentIEA:Ensembl
Metanephric part of ureteric bud developmentIEA:Ensembl
Metanephric renal vesicle morphogenesisIEA:Ensembl
Metanephric S-shaped body morphogenesisIEA:Ensembl
Motor neuron axon guidanceISS:UniProtKB
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Nephric duct elongationIEA:Ensembl
Nephric duct morphogenesisISS:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Oviduct developmentISS:UniProtKB
Oviduct epithelium developmentISS:UniProtKB
Paramesonephric duct developmentISS:UniProtKB
Pattern specification processISS:UniProtKB
Positive regulation of anterior head developmentISS:UniProtKB
Positive regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Positive regulation of embryonic developmentISS:UniProtKB
Positive regulation of gastrulationISS:UniProtKB
Positive regulation of nephron tubule epithelial cell differentiationISS:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Post-embryonic developmentISS:UniProtKB
Primitive streak formationISS:UniProtKB
Pronephros developmentIEA:Ensembl
Regulation of gene expressionISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Renal vesicle morphogenesisISS:UniProtKB
Retina layer formationISS:UniProtKB
S-shaped body morphogenesisISS:UniProtKB
Somite rostral/caudal axis specificationIEA:Ensembl
Spinal cord association neuron differentiationISS:UniProtKB
Telencephalon developmentIEA:Ensembl
Transcription by RNA polymerase IIISS:UniProtKB
Ureter morphogenesisIEA:Ensembl
Ureteric bud developmentISS:UniProtKB
Urogenital system developmentISS:UniProtKB
Uterine epithelium developmentISS:UniProtKB
Uterus developmentISS:UniProtKB
Vagina developmentISS:UniProtKB
Ventral spinal cord developmentIEA:Ensembl
Cellular Location
Nucleus

Moshfegh, C., Rambow, S. G., Domenig, S. A., Pieńkowska-Schelling, A., Bleul, U., & Vogel, V. (2022). Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1). Stem cell research, 61, 102780.

Singh, N., Singh, D., & Modi, D. (2022). LIM homeodomain (LIM-HD) genes and their co-regulators in developing reproductive system and disorders of sex development. Sexual Development, 16(2-3), 147-161.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Yasuoka, Y., & Taira, M. (2021). LIM homeodomain proteins and associated partners: Then and now. Current topics in developmental biology, 145, 113-166.

Lu, C., Duan, C. C., & Bing, H. (2021). LIM Homeobox Transcription Factors as Novel Prognosis Biomarkers in Head and Neck Squamous Cell Carcinoma.

McMahon, R., Sibbritt, T., Salehin, N., Osteil, P., & Tam, P. P. (2019). Mechanistic insights from the LHX1‐driven molecular network in building the embryonic head. Development, growth & differentiation, 61(5), 327-336.

Bethea, M., Liu, Y., Wade, A. K., Mullen, R., Gupta, R., Gelfanov, V., ... & Hunter, C. S. (2019). The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis. American Journal of Physiology-Endocrinology and Metabolism, 316(3), E397-E409.

Sibbritt, T., Ip, C. K., Khoo, P. L., Wilkie, E., Jones, V., Sun, J. Q., ... & Fossat, N. (2018). A gene regulatory network anchored by LIM homeobox 1 for embryonic head development. genesis, 56(9), e23246.

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For research use only. Not intended for any clinical use.

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