LHX1

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer. [provided by RefSeq]

Full Name

LHX1

Function

Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.

Biological Process

Anatomical structure formation involved in morphogenesisISS:UniProtKB
Anatomical structure morphogenesisISS:UniProtKB
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Anterior/posterior axis specificationISS:UniProtKB
Anterior/posterior pattern specificationISS:UniProtKB
Branching involved in ureteric bud morphogenesisIEA:Ensembl
Cell-cell signalingISS:UniProtKB
Cellular response to fibroblast growth factor stimulusIEA:Ensembl
Cerebellar Purkinje cell differentiationISS:UniProtKB
Cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferationISS:UniProtKB
Cerebellum developmentISS:UniProtKB
Cervix developmentISS:UniProtKB
Comma-shaped body morphogenesisISS:UniProtKB
Dorsal spinal cord interneuron posterior axon guidanceISS:UniProtKB
Dorsal/ventral pattern formationISS:UniProtKB
Ectoderm formationISS:UniProtKB
Embryonic pattern specificationISS:UniProtKB
Embryonic retina morphogenesis in camera-type eyeISS:UniProtKB
Embryonic viscerocranium morphogenesisISS:UniProtKB
Endoderm formationISS:UniProtKB
Epithelium developmentISS:UniProtKB
Forebrain regionalizationISS:UniProtKB
Gastrulation with mouth forming secondISS:UniProtKB
Head developmentISS:UniProtKB
Horizontal cell localizationIEA:Ensembl
Kidney developmentISS:UniProtKB
Lateral motor column neuron migrationISS:UniProtKB
Mesendoderm developmentIEA:Ensembl
Mesonephric duct developmentIEA:Ensembl
Metanephric comma-shaped body morphogenesisIEA:Ensembl
Metanephric glomerulus developmentIEA:Ensembl
Metanephric part of ureteric bud developmentIEA:Ensembl
Metanephric renal vesicle morphogenesisIEA:Ensembl
Metanephric S-shaped body morphogenesisIEA:Ensembl
Motor neuron axon guidanceISS:UniProtKB
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Nephric duct elongationIEA:Ensembl
Nephric duct morphogenesisISS:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Oviduct developmentISS:UniProtKB
Oviduct epithelium developmentISS:UniProtKB
Paramesonephric duct developmentISS:UniProtKB
Pattern specification processISS:UniProtKB
Positive regulation of anterior head developmentISS:UniProtKB
Positive regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Positive regulation of embryonic developmentISS:UniProtKB
Positive regulation of gastrulationISS:UniProtKB
Positive regulation of nephron tubule epithelial cell differentiationISS:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Post-embryonic developmentISS:UniProtKB
Primitive streak formationISS:UniProtKB
Pronephros developmentIEA:Ensembl
Regulation of gene expressionISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Renal vesicle morphogenesisISS:UniProtKB
Retina layer formationISS:UniProtKB
S-shaped body morphogenesisISS:UniProtKB
Somite rostral/caudal axis specificationIEA:Ensembl
Spinal cord association neuron differentiationISS:UniProtKB
Telencephalon developmentIEA:Ensembl
Transcription by RNA polymerase IIISS:UniProtKB
Ureter morphogenesisIEA:Ensembl
Ureteric bud developmentISS:UniProtKB
Urogenital system developmentISS:UniProtKB
Uterine epithelium developmentISS:UniProtKB
Uterus developmentISS:UniProtKB
Vagina developmentISS:UniProtKB
Ventral spinal cord developmentIEA:Ensembl

Cellular Location

Nucleus