Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-LHX2 Recombinant Antibody (CBT844) (V2LY-0625-LY3236)


See all LHX2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT844
Antibody Isotype
IgG
Application
WB, IF, ICC, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human LHX2 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
IF1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LHX2
Entrez Gene ID
9355
UniProt ID
P50458
Function
Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).
Biological Process
Axon extensionIEA:Ensembl
Axon guidanceIEA:Ensembl
Cerebral cortex developmentIEA:Ensembl
Dorsal/ventral pattern formationIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Maintenance of epithelial cell apical/basal polarityIEA:Ensembl
Mesoderm developmentIEA:Ensembl
Negative regulation of gene expression, epigeneticIEA:Ensembl
Negative regulation of neurogenesisIEA:Ensembl
Negative regulation of transcription regulatory region DNA bindingIEA:Ensembl
Neural tube closureIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Olfactory bulb developmentIEA:Ensembl
Positive regulation of neural precursor cell proliferationIEA:Ensembl
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Telencephalon regionalizationIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Xiao, J., Xie, Y., Duan, Q., Liu, T., Ye, R., Duan, X., ... & Liu, F. (2023). LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models. International Heart Journal, 64(4), 750-758.

Singh, N., Singh, D., Bhide, A., Sharma, R., Bhowmick, S., Patel, V., & Modi, D. (2023). LHX2 in germ cells control tubular organization in the developing mouse testis. Experimental Cell Research, 425(1), 113511.

Mosca, N., Khoubai, F. Z., Fedou, S., Carrillo-Reixach, J., Caruso, S., Rio-Alvarez, D., ... & Grosset, C. F. (2022). LIM homeobox-2 suppresses hallmarks of adult and pediatric liver cancers by inactivating MAPK/ERK and Wnt/beta-catenin pathways. Liver Cancer, 11(2), 126-140.

Singh, N., Singh, D., & Modi, D. (2022). LIM homeodomain (LIM-HD) genes and their co-regulators in developing reproductive system and disorders of sex development. Sexual Development, 16(2-3), 147-161.

Britton, J. C., Cooper, A. M., Pira, C. U., & Oberg, K. C. (2022). Regulation of LIM homeodomain 2 (Lhx2) in the distal limb bud during patterning and development. The FASEB Journal, 36.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Wheaton, B. J., Häggström, S. L., Muppavarapu, M., González‐Castrillón, L. M., & Wilson, S. I. (2022). Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates. Developmental Dynamics, 251(7), 1223-1243.

Yasuoka, Y., & Taira, M. (2021). LIM homeodomain proteins and associated partners: Then and now. Current topics in developmental biology, 145, 113-166.

Miyoshi, M., Kakinuma, S., Kamiya, A., Tsunoda, T., Tsuchiya, J., Sato, A., ... & Watanabe, M. (2019). LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Scientific Reports, 9(1), 2072.

Chou, S. J., & Tole, S. (2019). Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development. Brain research, 1705, 1-14.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LHX2 Recombinant Antibody (CBT844)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry