Mouse Anti-LHX2 Recombinant Antibody (CBYCL-295) (CBMAB-L0196-YC)

Name: Mouse Anti-LHX2 Recombinant Antibody (CBYCL-295)
SKU: CBMAB-L0196-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-295

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LHX2

Introduction

LHX2 is a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.

Entrez Gene ID

9355

UniProt ID

P50458

Alternative Names

hLhx2; LH2

Function

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).

Biological Process

Axon extensionIEA:Ensembl
Axon guidanceIEA:Ensembl
Cerebral cortex developmentIEA:Ensembl
Dorsal/ventral pattern formationIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Maintenance of epithelial cell apical/basal polarityIEA:Ensembl
Mesoderm developmentIEA:Ensembl
Negative regulation of gene expression, epigeneticIEA:Ensembl
Negative regulation of neurogenesisIEA:Ensembl
Negative regulation of transcription regulatory region DNA bindingIEA:Ensembl
Neural tube closureIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Olfactory bulb developmentIEA:Ensembl
Positive regulation of neural precursor cell proliferationIEA:Ensembl
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Telencephalon regionalizationIEA:Ensembl

Cellular Location

Nucleus

Xiao, J., Xie, Y., Duan, Q., Liu, T., Ye, R., Duan, X., ... & Liu, F. (2023). LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models. International Heart Journal, 64(4), 750-758.

Singh, N., Singh, D., Bhide, A., Sharma, R., Bhowmick, S., Patel, V., & Modi, D. (2023). LHX2 in germ cells control tubular organization in the developing mouse testis. Experimental Cell Research, 425(1), 113511.

Mosca, N., Khoubai, F. Z., Fedou, S., Carrillo-Reixach, J., Caruso, S., Rio-Alvarez, D., ... & Grosset, C. F. (2022). LIM homeobox-2 suppresses hallmarks of adult and pediatric liver cancers by inactivating MAPK/ERK and Wnt/beta-catenin pathways. Liver Cancer, 11(2), 126-140.

Singh, N., Singh, D., & Modi, D. (2022). LIM homeodomain (LIM-HD) genes and their co-regulators in developing reproductive system and disorders of sex development. Sexual Development, 16(2-3), 147-161.

Britton, J. C., Cooper, A. M., Pira, C. U., & Oberg, K. C. (2022). Regulation of LIM homeodomain 2 (Lhx2) in the distal limb bud during patterning and development. The FASEB Journal, 36.

Gao, P., Sun, N., Zhao, T., Sun, Y., Gu, J., Ma, D., ... & Qi, X. (2022). Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation, 1(3), 252-269.

Wheaton, B. J., Häggström, S. L., Muppavarapu, M., González‐Castrillón, L. M., & Wilson, S. I. (2022). Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates. Developmental Dynamics, 251(7), 1223-1243.

Yasuoka, Y., & Taira, M. (2021). LIM homeodomain proteins and associated partners: Then and now. Current topics in developmental biology, 145, 113-166.

Miyoshi, M., Kakinuma, S., Kamiya, A., Tsunoda, T., Tsuchiya, J., Sato, A., ... & Watanabe, M. (2019). LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Scientific Reports, 9(1), 2072.

Chou, S. J., & Tole, S. (2019). Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development. Brain research, 1705, 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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