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Mouse Anti-Lifr Recombinant Antibody (CBYJL-2388) (CBMAB-L2701-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lif Receptor Alpha (Lifr). The antibody can be used for immunoassay techniques, such as ELISA.
See all Lifr antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYJL-2388
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant Rat LIFR/CD118 protein.
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leukemia inhibitory factor receptor alpha
Introduction
Lifr is alpha chain of leukemia inhibitory factor. Lifr is also a glycoprotein and growth factor.
Entrez Gene ID
81680
UniProt ID
P42703
Alternative Names
leukemia inhibitory factor receptor; LIF receptor; LIF-R; leukemia inhibitor factor receptor alpha-chain; leukemia inhibitory factor receptor alpha
Function
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Ciliary neurotrophic factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Leukemia inhibitory factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Response to cytokineManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Isoform 1:
Cell membran
Isoform 2:
Secreted
Involvement in disease
Stueve-Wiedemann syndrome (STWS):
Severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue.
A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.
Topology
Extracellular: 45-833
Helical: 834-858
Cytoplasmic: 859-1097

Di Giorgio, C., Bellini, R., Lupia, A., Massa, C., Bordoni, M., Marchianò, S., ... & Fiorucci, S. (2023). Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma. Frontiers in Oncology, 13, 1140730.

Di Giorgio, C., Morretta, E., Lupia, A., Bellini, R., Massa, C., Urbani, G., ... & Fiorucci, S. (2023). Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis. bioRxiv, 2023-09.

Christianson, J., Oxford, J. T., & Jorcyk, C. L. (2021). Emerging perspectives on leukemia inhibitory factor and its receptor in cancer. Frontiers in Oncology, 11, 693724.

Vaziri, N., Shariati, L., Zarrabi, A., Farazmand, A., & Haghjooy Javanmard, S. (2021). Cancer-associated fibroblasts regulate the plasticity of breast cancer stemness through the production of leukemia inhibitory factor. Life, 11(12), 1298.

Wang, T., Yan, R., Xu, X., Yu, H., Wu, J., Yang, Y., & Li, W. (2019). Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells. Molecular Medicine Reports, 19(6), 4719-4726.

Lei, C., Lv, S., Wang, H., Liu, C., Zhai, Q., Wang, S., ... & Wei, Q. (2018). Leukemia inhibitory factor receptor suppresses the metastasis of clear cell renal cell carcinoma through negative regulation of the yes-associated protein. DNA and Cell Biology, 37(8), 659-669.

Davis, S. M., & Pennypacker, K. R. (2018). The role of the leukemia inhibitory factor receptor in neuroprotective signaling. Pharmacology & therapeutics, 183, 50-57.

Li, X., Yang, Y., Yan, R., Xu, X., Gao, L., Mei, J., ... & Wang, T. (2018). miR-377-3p regulates adipogenic differentiation of human bone marrow mesenchymal stem cells by regulating LIFR. Molecular and Cellular Biochemistry, 449, 295-303.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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