Mouse Anti-LIFR Recombinant Antibody (MMHAR-1) (CBMAB-I0890-YY)

Name: Mouse Anti-LIFR Recombinant Antibody (MMHAR-1)
SKU: CBMAB-I0890-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

MMHAR-1

Application

ELISA, FC, WB

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

5% trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

leukemia inhibitory factor receptor alpha

Introduction

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias.

Entrez Gene ID

3977

UniProt ID

P42702

Alternative Names

SWS; SJS2; STWS; CD118; LIF-R

Function

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

Biological Process

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Ciliary neurotrophic factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Leukemia inhibitory factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Response to cytokineManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Isoform 1:
Cell membran
Isoform 2:
Secreted

Involvement in disease

Stueve-Wiedemann syndrome (STWS):
Severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue.
A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.

Topology

Extracellular: 45-833
Helical: 834-858
Cytoplasmic: 859-1097

Di Giorgio, C., Bellini, R., Lupia, A., Massa, C., Bordoni, M., Marchianò, S., ... & Fiorucci, S. (2023). Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma. Frontiers in Oncology, 13, 1140730.

Di Giorgio, C., Morretta, E., Lupia, A., Bellini, R., Massa, C., Urbani, G., ... & Fiorucci, S. (2023). Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis. bioRxiv, 2023-09.

Christianson, J., Oxford, J. T., & Jorcyk, C. L. (2021). Emerging perspectives on leukemia inhibitory factor and its receptor in cancer. Frontiers in Oncology, 11, 693724.

Vaziri, N., Shariati, L., Zarrabi, A., Farazmand, A., & Haghjooy Javanmard, S. (2021). Cancer-associated fibroblasts regulate the plasticity of breast cancer stemness through the production of leukemia inhibitory factor. Life, 11(12), 1298.

Wang, T., Yan, R., Xu, X., Yu, H., Wu, J., Yang, Y., & Li, W. (2019). Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells. Molecular Medicine Reports, 19(6), 4719-4726.

Lei, C., Lv, S., Wang, H., Liu, C., Zhai, Q., Wang, S., ... & Wei, Q. (2018). Leukemia inhibitory factor receptor suppresses the metastasis of clear cell renal cell carcinoma through negative regulation of the yes-associated protein. DNA and Cell Biology, 37(8), 659-669.

Davis, S. M., & Pennypacker, K. R. (2018). The role of the leukemia inhibitory factor receptor in neuroprotective signaling. Pharmacology & therapeutics, 183, 50-57.

Li, X., Yang, Y., Yan, R., Xu, X., Gao, L., Mei, J., ... & Wang, T. (2018). miR-377-3p regulates adipogenic differentiation of human bone marrow mesenchymal stem cells by regulating LIFR. Molecular and Cellular Biochemistry, 449, 295-303.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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