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Human Anti-LILRA2 Recombinant Antibody (CBXC-0752) (CBMAB-C1866-CQ)

This product is a recombinant human antibody that recognizes LILRA2. The antibody CBXC-0752 can be used for immunoassay techniques such as: FC.
See all LILRA2 antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0752
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
Entrez Gene ID
11027
UniProt ID
Q8N149
Alternative Names
CD85H; ILT1; LIR-7; LIR7
Function
Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839).
Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839).
Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839).
Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839).
Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839).
In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404).
In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506).
Does not bind class I MHC antigens (PubMed:19230061).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIEA:UniProtKB-KW
Innate immune response activating cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of granulocyte colony-stimulating factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Isoform 4:
Secreted
Topology
Extracellular: 24-449
Helical: 450-470
Cytoplasmic: 471-483
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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