LILRA2

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM

Full Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

Function

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839).
Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839).
Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839).
Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839).
Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839).
In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404).
In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506).
Does not bind class I MHC antigens (PubMed:19230061).

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIEA:UniProtKB-KW
Innate immune response activating cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of granulocyte colony-stimulating factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Isoform 4:
Secreted

Topology

Extracellular: 24-449
Helical: 450-470
Cytoplasmic: 471-483