Human Recombinant LILRA2 protein, hFc Tag (V2LY-0526-LY4973)

Name: Human Recombinant LILRA2 protein, hFc Tag
SKU: V2LY-0526-LY4973
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant LILRA2 protein, hFc Tag consist of Amino Acid: 1-449 and predicts a molecular mass of 73.7 kDa.

Molecule Mass

73.7 kDa

Sequence

Amino Acid: 1-449

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Glycine, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

Function

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839).
Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839).
Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839).
Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839).
Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839).
In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404).
In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506).
Does not bind class I MHC antigens (PubMed:19230061).

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIEA:UniProtKB-KW
Innate immune response activating cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of granulocyte colony-stimulating factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane
Isoform 4:
Secreted

Topology

Extracellular: 24-449
Helical: 450-470
Cytoplasmic: 471-483

Zhang, Y., Zhang, L., Zhao, Y., Wang, S., & Feng, L. (2023). Overexpression of LILRA2 indicated poor prognosis of ovarian carcinoma: A new potential biomarker and therapeutic target. Taiwanese Journal of Obstetrics and Gynecology, 62(1), 77-88.

Yamazaki, R., Furukawa, A., Hirayasu, K., Yumoto, K., Fukuhara, H., Arase, H., & Maenaka, K. (2020). Molecular mechanism of the recognition of bacterially cleaved immunoglobulin by the immune regulatory receptor LILRA2. Journal of Biological Chemistry, 295(28), 9531-9541.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LILRA2 protein, ECD, His Tag (CAT#: V2LY-0526-LY4972)

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Isotype control

For research use only. Not intended for any clinical use.

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