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Mouse Anti-LILRA4 Recombinant Antibody (CBFYC-0342) (CBMAB-C0381-FY)

This product is mouse antibody that recognizes LILRA4. The antibody CBFYC-0342 can be used for immunoassay techniques such as: FC.
See all LILRA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0342
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leukocyte Immunoglobulin Like Receptor A4
Introduction
This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response.
Entrez Gene ID
23547
UniProt ID
P59901
Alternative Names
ILT7; CD85g
Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354).
Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760).
Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439).
Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354).
Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Fc-epsilon receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Negative regulation of interferon-alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 7 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 9 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-446
Helical: 447-467
Cytoplasmic: 468-499
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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