LILRA4

LILRA4 (Leukocyte Immunoglobulin Like Receptor A4) is a Protein Coding gene. Diseases associated with LILRA4 include Blastic Plasmacytoid Dendritic Cell. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Osteoclast differentiation. An important paralog of this gene is LILRB3.
Full Name
Leukocyte Immunoglobulin Like Receptor A4
Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354).
Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760).
Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439).
Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354).
Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Fc-epsilon receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Negative regulation of interferon-alpha productionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 7 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of toll-like receptor 9 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 24-446
Helical: 447-467
Cytoplasmic: 468-499
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Anti-LILRA4 antibodies

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Mouse Anti-LILRA4 Recombinant Antibody (CBWJC-2322) (CBMAB-C3235WJ)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2322
Application*: F, FN
Datasheet SDS

Human Anti-LILRA4 Recombinant Antibody (CBXC-0704) (CBMAB-C1817-CQ)

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Target: LILRA4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0704
Application*: F
Datasheet SDS

Mouse Anti-LILRA4 Recombinant Antibody (CBFYC-0342) (CBMAB-C0381-FY)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0342
Application*: F
Datasheet SDS

Mouse Anti-LILRA4 Recombinant Antibody (CBYCL-321) (CBMAB-L0222-YC)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCL-321
Application*: F
Datasheet SDS

Mouse Anti-LILRA4 Recombinant Antibody (CBT3364) (V2LY-0625-LY1499)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3364
Application*: IH, F
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Mouse Anti-LILRA4 Recombinant Antibody (CBT2522) (V2LY-0625-LY1498)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2522
Application*: WB, IC, F
Datasheet SDS

Mouse Anti-LILRA4 Recombinant Antibody (656688) (CBMAB-I1513-YY)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 656688
Application*: F, MC
Datasheet SDS

Mouse Anti-LILRA4 Recombinant Antibody (17G10.2) (CBMAB-L1546-YJ)

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Target: LILRA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 17G10.2
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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